Photo exhibition: My Beautiful Skin (Min smukke hud)
Grantee: Charlotte Näslund Koch, Herlev-Gentofte Hospital
Amount: DKK 210,000
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
My Beautiful Skin (Min smukke hud) is the name of a photo project that aims to address the stigma of skin diseases and promote a more inclusive and natural beauty ideal. The recognized photographer Marie Hald has been commissioned to take a series of art photos, depicting 20 patients with different skin disease.
The photos will be exhibited at Department of Dermatology and Allergy – Herlev and Gentofte Hospital, accompanied by evidence-based information about the relevant skin disease. The photo exhibition is driven by clinical researchers in collaboration with the hospital’s communication team.
Digitalt univers til databearbejdning af citizen science-genererede forskningsdata i gymnasiet
Grantee: Marie Rathcke Lillemark, Statens Naturhistoriske Museum
Amount: DKK 1,811,250
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
The Natural History Museum of Denmark, University of Copenhagen will establish a free online platform for high schools to support the education of ‘data literate’ citizens with hands-on skills in answering interdisciplinary questions through scientific methodology. The platform will provide free access for Danish high schools to data obtained in the Next Generation Lab initiative, an ongoing citizen science initiative in which students analyze archaeological findings at the museum’s lab using scientific methods, thereby generating large amounts of raw research data. The portal will enable students from all over Denmark to work directly with this data, guided by new educational material that supports its relevance within or across topics such as biology, biotechnology, chemistry, history, Danish language and literature, physics, and social studies.
Astronomy and natural science for kids (Astronomi og naturvidenskab i børnehøjde)
Grantee: Mille Marta Andersen, Go Zebra
Amount: DKK 978,420
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
Go Zebra, a non-profit organization dedicated to stimulating children’s curiosity and bridging it to problem-solving and societal challenges through educational material with a special focus on engineering and innovation, joins forces with astrophysicist and science communicator Tina Ibsen in developing a free educational course on astronomy aimed for 4th-grade teachers and pupils. The developed material will become available for free on MeeBook (the learning platform most widely used by Danish schools), and classes participating in the project will have workshops facilitated by Go Zebra at their schools.
The overall ambition is to instill confidence in children that they can understand the world and have the capabilities to solve problems.
Sustaining the Voice of Science: Increase the Impact of STEM Communication Activities at DTU Skylab
Grantee: Christian Daniel Koldbech, DTU Skylab
Amount: DKK 998,333
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
DTU Skylab will produce two video series, in total ten videos, to promote interest in STEM innovation and entrepreneurship. One of the series will consist of documentaries presenting the most significant innovations that have been realized within the DTU Skylab framework. The other series will consist of interviews with in-house experts and Skylab-based student entrepreneurs sharing their experiences and advice for students.
The videos will provide behind-the-scenes insights into the nature of scientific and technological innovation and entrepreneurship.
The dermatologist’s table (Hudlægens bord)
Grantee: Vibeke Hjortlund, Videnskab.dk
Amount: DKK 1,262,415
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
Videnskab.dk will produce a podcast series of 12 episodes that disseminate science-based knowledge to the public, about skin health and skin/venereal diseases. The series will be hosted by an MD in dermatology and will address several topics selected by a medical panel to reflect frequently asked questions from patients. Each episode will introduce novel research within the field with potential for enabling new or improved treatment, facilitated by Danish researchers. The podcasts are supplemented with popular science articles and short videos.
Structural dissection and dynamic insights into the molecular switch of mast cells and basophils: a blueprint for novel urticaria therapies
Grantee: Rosaria Gandini, Assistant Professor, Aarhus University
Amount: DKK 3,462,144
Grant category: Research Grants in open competition
Year: 2024
Geography: Denmark
Rosaria Gandini’s project investigates the molecular details of the IgE-FceRI complex and its functioning on mast cells and basophils in order to improve treatment opportunities for urticaria.
Urticaria, a common inflammatory skin disorder characterized by itchy wheals, angioedema, or both, manifests in acute (AU) and chronic (CU) forms. It significantly impairs patients’ quality of life, causing sleep disturbances due to pruritus, fatigue, and anxiety. The symptoms arise from the activation of skin mast cells and basophils, leading to the release of histamine and other inflammatory mediators. This activation is initiated by cross-linking and clustering of the complexes between immunoglobulin E (IgE) and its high-affinity receptor, FceRI, which is expressed on the surface of these cells.
The FceRI-IgE complex hence acts as a powerful molecular switch, which initiates the inflammatory cascade and thus provides an attractive target for drug intervention. The structural basis of this activity, however, remains open.
Rosaria Gandini’s project aims to determine the structure of the FceRI-IgE membrane complex using state of the art Cryo Electron Microscopy (cryo-EM).
Successful elucidation of the molecular details of the entire complex and its conformations will allow identification of specific regions on FceRI for targeted intervention. This knowledge will deepen the understanding of the interaction of antibodies with Fc receptors in general and may pave the way for the development of specific and effective treatment of urticaria and related disorders.
Protein stability and misfolding in keratin disorders
Grantee: Rasmus Hartmann-Petersen, Professor, University of Copenhagen
Amount: DKK 2,600,678
Grant category: Research Grants in open competition
Year: 2024
Geography: Denmark
Rasmus Hartmann-Petersen’s project aims to characterize all possible missense variants (changes in genes which introduce a different amino acid in the resulting protein) in human keratins and investigate the importance of these variants in associated diseases.
Keratins are intermediate filament proteins that form a cytoskeletal network within cells. They are expressed in a tissue-specific fashion and form heterodimers, which then further oligomerize into filaments. Variants in several keratin encoding genes are linked to a range of hereditary disorders, including several epidermal skin diseases. On the molecular level, some pathogenic keratin variants appear to cause aggregation of the keratins.
In Rasmus Hartmann-Petersen’s project it is hypothesized that most keratin-disorders are protein misfolding diseases, i.e. diseases where the underlying genetic variants cause misfolding of the encoding protein. Rasmus and his team aim to explore this hypothesis by using computational tools, including large language models (a specific form of AI). They will test the validity of the computational predictions through focused cellular studies on selected keratins and identify components regulating keratin turnover.
The results will highlight the underlying molecular mechanisms for keratin-linked human disorders and provide predictions on the severity of all possible (both known and yet unobserved) coding variants in human keratin genes. The results could be of diagnostic value, but may also highlight the cellular protein folding and protein quality control machinery as potential therapeutic targets.
Architecture of the Herpes simplex replication machinery and its inhibitors
Grantee: Eva Kummer, Associate Professor, Copenhagen University
Amount: DKK 4,902,307
Grant category: Research Grants in open competition
Year: 2024
Geography: Denmark
Eva Kummer’s project targets to improve our understanding of the replication machinery of the skin-infecting herpes simplex virus (HSV) in order to improve and expand treatment opportunities.
HSV is one of the most widespread viral infections. The virus persists lifelong in the nerve system of the host and causes recurrent infections with mild to severe symptoms.
Since decades, treatment of herpes infections has exclusively targeted the viral replicative DNA polymerase (an enzyme that copies the viral DNA) using nucleoside analogs. However, resistance to current nucleoside analogs is emerging necessitating the search for alternative targets.
A major caveat in developing anti-herpetic compounds is a lack of structural information of other components of the herpes simplex replication system, which are likely strong candidates for targeted drug development. Eva Kummer and her team will use cryo-electron microscopy to visualize the architecture and working principles of the protein complexes that drive herpes simplex replication. They will also aim to clarify how novel anti-herpetic drugs block the viral replication machinery and why naturally occurring resistance mutations inhibit their action.
Overall, the project will generate structural and functional insights of the HSV replication strategy and potentially improve and accelerate anti-viral drug design.
Targeted and localized skin inflammation as a potential immunotherapy against cancer
Grantee: Vasileios Bekiaris, Associate Professor, Technical University of Denmark
Amount: DKK 3,987,557
Grant category: Serendipity Grants
Year: 2023
Geography: Denmark
Vasileios Bekiaris will investigate how an observed adverse impact of a drug candidate in psoriasis may be converted to a potential treatment of cancer.
Vasileios Bekiaris and his team have been studying the mechanisms by which psoriasis is induced for several years, and their goal was to find ways to suppress it. They have discovered a molecule that is necessary for the generation and function of the immune cells responsible for causing psoriasis. Moreover, they have access to a drug that targets and neutralizes this molecule, and therefore they thought that it could potentially inhibit psoriasis. Contrary to what they expected, the drug induced inflammation and exacerbated psoriasis instead of treating it. It is known that for many cancers, inflammation promotes favourable protective immunity and helps the efficacy of immunotherapy. Using a mouse melanoma model, Vasileios Bekiaris and his team have managed to generate data suggesting that the pro-inflammatory drug could in fact suppress tumour growth.
Vasileios Bekiaris will therefore investigate the drug’s potential in cancer treatment and, if successful, may open possibilities for a new immunotherapy against skin cancers. Vasileios Bekiaris and his team also believe that this data will continue their contribution towards understanding how skin inflammation is mediated.
An unexpected link between age-associated B cells and CD8 T cells
Grantee: Søren Degn, Associate Professor, Aarhus University
Amount: DKK 3,337,538
Grant category: Serendipity Grants
Year: 2023
Geography: Denmark
Søren Degn will investigate a novel link between age-related B cells (ABCs) and cytotoxic CD8+ T cells.
Søren Degn and his team have discovered a new and unexpected link between a type of immune cells that normally produce antibodies (B cells) and a type of immune cells that are responsible for eliminating the body’s own cells when they are infected or become cancerous (CD8+ T cells). Their preliminary findings indicate that this link may play an important role when the immune system is erroneously activated, when an infection cannot be cleared, or when a cancer is established. It is not known which exact signals are responsible for the communication between these two cell types, and whether it occurs directly or via a third-party messenger. However, it is known that it occurs in the spleen, an important immune organ, which filters the blood and prevents infections, but also plays a critical role in autoimmune diseases.
The intention of Søren Degn is to understand the cellular and molecular mechanisms behind this novel link. An increased understanding may enable new therapeutic strategies in the future across a range of important diseases such as inflammatory skin disorders, autoimmune diseases, and cancer.