ESDR Future Leaders Academy 2025
Grantee: Thomas Florestan, European Society for Dermatological Research (ESDR)
Amount: EUR 25,000
Grant category: Research Networking
Year: 2025
Geography: Switzerland
ESDR Future Leaders Academy, a 3-day event from 6.-8. November 2025 held in Nice with the theme ’Excellence in skin science, future is ours’. The goal of this initiative is to foster excellence in academic dermatology and encourage gifted young dermatologists to further pursue their careers through guidance and mentoring. The program is primarily open to European residents currently engaged in skin-related research (MD, PhD, Post-Doc). There will be 25 applicants who will be selected to present their current research, along with 7 mentors who will make a more personal and inspiring presentation. Besides scientific sessions there is a strong emphasis on encouraging young people to network and to exchange ideas during the academy.
SID Resident and Post Doc Retreat
Grantee: Rebecca Minnillo, Society for Investigative Dermatology (SID)
Amount: EUR 25,000
Grant category: Research Networking
Year: 2025
Geography: USA
The Resident and Post Doc Retreat is a conference hosted by the Society for Investigative Dermatology (SID) each year since 2001. The program format provides a protected space in which residents can interact with senior faculty and established investigators for the purpose of fostering attendees’ interest in academic research careers. The program is a combination of formal lectures and presentations, informal discussions, brainstorming sessions and social activities. The retreat is held at the time of the SID annual meeting, which allows attendees to establish connections with each other, and to other meeting attendees. These social networks foster collegiality, collaborations, and appreciation for the creative, multidisciplinary nature of science and other productive interactions.
From Flexibility to Dysfunction: The Impact of Oxidative Stress on the Structural Integrity of Skin Elastin
Grantee: Andrea Heinz, Associate Professor, LEO Foundation Center for Cutaneous Drug Delivery, University of Copenhagen, Denmark
Amount: DKK 3,987,617
Grant category: Research Grants in open competition
Year: 2025
Geography: Denmark
Elastin is a structural protein essential for human life. It provides the elasticity needed for organs like skin, lungs, and blood vessels, allowing your skin to stretch, your lungs to expand for breathing and your blood to flow smoothly. As we age, factors like oxidative stress can make elastin stiffer, reducing the skin’s elasticity and accelerating the aging process. This can lead to skin conditions, such as thickening and furrowing or increased fragility. This project uses advanced analytical techniques to investigate how oxidative damage affect elastin’s structure and stability, starting with its building block, tropoelastin, and extending to skin elastin. Our goal is to understand how these alterations contribute to elastic fiber breakdown and tissue dysfunction. Ultimately, this knowledge will help us understand how elastin damage drives disease and tissue degeneration, which could lead to better treatments that protect tissue elasticity and improve overall health.
NyNano-Heal: New Nano-Healing Systems for Epidermolysis Bullosa
Grantee: Wojciech Chrzanowski, Professor of Nanomedicine, The University of Sydney, Australia
Amount: DKK 2,981,787
Grant category: Research Grants in open competition
Year: 2025
Geography: Australia
Imagine living with a condition where your skin is as fragile as a butterfly’s wings, constantly blistering and tearing. This is what people with Epidermolysis Bullosa experience. Existing treatments only provide temporary relief and do not address the root causes of the condition. Our Team have created tiny multifunctional robots that are solution for this debilitating disease. These robots carry simultaneously healing substances and bacteria-fighting agents. The healing substances activate different cells in the body to address the genetic issues of EB. The bacteria-fighting agents help the immune system, speed up healing, and fight infections. They also restore the skin’s natural balance, which helps prevent new blisters. These robots are delivered precisely to the damaged skin using advanced materials. This new method targets multiple aspects of the disease and offers a complete solution that is superior to current treatments, providing hope for those with EB.
SERS-Enabled Wound-Sampling Patches for Rapid Infection Monitoring
Grantee: Gohar Soufi, Postdoc, Technical University of Denmark, Denmark
Amount: DKK 3,999,657
Grant category: Research Grants in open competition
Year: 2025
Geography: Denmark
Millions of people suffer from infected wounds each year, which can lead to serious complications or even death if untreated. Current methods for diagnosing wound infections are slow and require specialized laboratories. Our project aims to create a simple, portable device that uses advanced materials to detect infections quickly and accurately right at the patient’s bedside. This technology could revolutionize how infections are diagnosed, helping doctors start treatments sooner and improving patient outcomes.
3D printing vascularised human skin implants from patient cells
Grantee: Kate Firipis, Research Officer, St Vincent's Institute of Medical Research, Australia
Amount: DKK 3,481,609
Grant category: Research Grants in open competition
Year: 2025
Geography: Australia
Using advances in stem cell and tissue engineering technologies, we will develop lab-grown skin tissue with 3D printed blood vessels derived from human induced pluripotent stem cells (stem cells that can be created from a single blood draw) as a personalised treatment for repairing large complex wounds. Improving skin reconstruction outcomes, including, aesthetics, function, blood vessel connection and removing the need to harvest healthy patient tissue that creates a secondary wound.
Interaction of Cutibacterium acnes (C. acnes) and the sebaceous gland in acne: Impact on the therapeutic management of acne
Grantee: Brigitte Dréno, Professor, Nantes Université, CHU Nantes, INSERM, IRS2/INCIT, UMR 1302, France
Amount: DKK 3,370,500
Grant category: Research Grants in open competition
Year: 2025
Geography: France
The main goal of this project is to determine how the beneficial bacterium, Cutibacterium acnes (C. acnes), that naturally lives on human skin causes acne. We hypothesize that changes in amount and types of oils (called sebum) secreted by skin oil glands may play a part in turning the beneficial C. acnes to disease-causing bacteria. Sebum profile changes may make C. acnes grow and behave differently, and cause skin inflammation. One way that sebum changes make C. acnes cause inflammation may be by extracellular vesicles, which are very small sacs released by the bacteria. Since androgen, a type of sex hormone, is known to increase sebum, medications that block androgens are currently used to treat acne. Thus, another aim of this project is to see if blocking androgens can manage acne by targeting sebum profile changes that affect inflammation caused by C. acnes. Our project will allow us to gain more knowledge on how acne develops and justify the use of androgen blockers as treatment.
Skin bacteria control of sensory function in response to environmental perturbations
Grantee: Simone Di Giovanni, Professor, Imperial College London, United Kingdom
Amount: DKK 3,997,382
Grant category: Research Grants in open competition
Year: 2025
Geography: United Kingdom
Skin innervation is our sensory interface with the ever-changing environment undergoing fluctuations in temperature and humidity. Sensation needs to account for these fluctuations to regulate sense of touch, pain, movement, learning and memory, sexual and social conduct. More than 100 million bacteria that reside on the human skin are the first line of response to environmental perturbations. Variable humidity, salinity, temperature, and oxygen affect bacteria metabolism and diversity. I therefore hypothesise that bacteria are required for sensory function affecting complex behaviours in response to perturbations in temperature and humidity. This bears implications for human physiology, health and resilience on earth.
Aplasia cutis pathogenesis provides key insights into skin and skin appendage biology
Grantee: Alexander Marneros, Associate Professor of Dermatology, Massachusetts General Hospital, United States
Amount: DKK 3,998,854
Grant category: Research Grants in open competition
Year: 2025
Geography: USA
To elucidate novel mechanisms that orchestrate skin formation we have focused on a genetic skin disease that manifests with scalp skin wounds at birth, aplasia cutis congenita (ACC). We found that the genes KCTD1 and KCTD15 are mutated in patients with ACC. These genes form a complex that inhibits the activity of AP-2 transcription factors. Inactivation of these genes in neural crest cells (NCCs), from which the mesenchymal cells of the midline cranial sutures are derived, results in ACC. Our data provide evidence that keratinocyte growth factors are secreted by these mesenchymal cells to promote the formation of the overlying epidermis. A key open question is now to understand the precise pathomechanisms that are downstream of this KCTD1/KCTD15 – AP-2 signaling axis, which we will explore in this proposal. These experiments are expected to provide exciting new insights into how skin formation is controlled, which likely has important clinical relevance for multiple skin diseases.
Memory ILC2s in atopic dermatitis
Grantee: Itziar Martinez Gonzalez, Assistant Professor, Karolinska Institutet, Sweden
Amount: DKK 3,753,750
Grant category: Research Grants in open competition
Year: 2025
Geography: Sweden
Atopic dermatitis (AD) is a common skin condition, characterized by itchy, inflamed skin. Identifying the allergens that trigger AD can be challenging, suggesting that allergen independent immune mechanisms are at play in AD. One key player in non-specific immune responses is a type of lymphocyte called ILC2. I discovered that ILC2s in human skin can remember previous activations and induce a more severe inflammation upon subsequent triggers. Memory ILC2s could be important in triggering the recurrent flare-ups seen in AD. Now, I aim to understand how memory ILC2s contribute to AD by studying how they are regulated at the cellular level and how they interact with their environment in the skin. We will also investigate if memory ILC2s play a role in the development of other allergic diseases associated with AD, like asthma. By studying how memory ILC2s function in AD, we hope to identify new ways to treat this chronic and often debilitating condition.