Dissecting the effects of sex hormones and sex chromosomes in heightened cutaneous inflammation in female mice
Grantee: Philip Scumpia, Associate Professor, The Regents of the University of California, Los Angeles
Amount: DKK 3,977,971
Grant category: Serendipity Grants
Year: 2024
Geography: USA
Philip Scumpia’s project will investigate a surprising discovery that links gender to differences in immune responses.
Philip Scumpia and his team created new formulations of biomaterials intended to improve cutaneous wound healing and decrease size of scars in his current LEO Foundation-funded project. While evaluating the immunological mechanisms, Philip and his team observed considerable variability in immune cell recruitment to the different hydrogels. After careful scrutiny they realized this variability was entirely due to the fact that female mice developed stronger immune responses to the hydrogel than male mice. Strikingly, female mice displayed a much earlier and more severe skin inflammation in other mouse models studied in the laboratory includingeczema, psoriasis, and sunburn.
Role for adipocytes and crosstalk with eosinophils in atopic dermatitis pathogenesis
Grantee: Nathan Archer, Assistant Professor, The Johns Hopkins University School of Medicine
Amount: DKK 3,999,693
Grant category: Serendipity Grants
Year: 2024
Geography: USA
Nathan Archer’s project investigates the surprising finding that dermal adipocytes and their crosstalk with eosinophils may play an important role in the development of atopic dermatitis.
The aim of Nathan Archer’s original project was to investigate the role of eosinophils, a type of immune cell, in the pronounced bacterial dysbiosis seen in relation to atopic dermatitis (AD). During those studies, Nathan Archer and his team serendipitously discovered an unexpected interaction of adipocytes with eosinophils in the skin, which was also associated with skin inflammation. This novel link will be investigated in Nathan’s project.
4th annual International Conference on the Science of Science and Innovation (ICSSI)
Grantee: Dashun Wang, Professor, Kellogg School of Management, Northwestern University
Amount: DKK 500,000
Grant category: Standalone grants
Year: 2024
Geography: USA
This interdisciplinary event will convene leading experts in the field of science of science and innovation, aiming to provide a multi-channel platform that brings together both producers (scientists from industry and academia) and consumers (policymakers, publishers, funders, administrators, etc.) of the field.
71st Annual Montagna Symposium: Skin of color Dermatology: The Intersection of Science and Society
Grantee: Oregon Health and Science University
Amount: DKK 170,783
Grant category: Research Networking
Year: 2024
Geography: USA
The goal of the 71st Annual Montagna Symposium, Skin of Color Dermatology: The Interaction of Science & Society, is to promote practicing clinicians, residents, trainees, basic and translational researchers who are underrepresented in science and medicine, assembling leading scientists and clinicians engaged in research and treatment of diseases that disproportionately affect skin of color to share knowledge and foster collaborations.
The event will take place on 17-21 October 2024 in Washington, USA and aim to enable interaction between new and established scientists and dermatologists who work collectively to advance the field of skin research. The format will include short talks organized in sessions by topic, with time for questions and discussion. Young investigators get the opportunity to interact with experienced researchers and clinicians in their fields both formally and informally throughout the meeting, and the meeting provides participants with a springboard for new research activities or clinical practices.
Development of novel RNA replicon vectors for treatment of skin genetic disorders
Grantee: Xiaoyang Wu, Associate Professor, University of Chicago
Amount: DKK 4,000,000
Grant category: Research Grants in open competition
Year: 2024
Geography: USA
Xiaoyang Wu’s project aims to engineer self-amplifying RNA vector as a platform for gene therapy of recessive X-linked ichthyosis, with potential for treatment of other skin diseases.
Skin ichthyoses are a group of heterogeneous genetic diseases that are characterized by hyperkeratosis, localized or generalized scaling, and often associated with xerosis, hypohidrosis, erythroderma, and recurrent infections. So far, mutations in more than 50 genes have been shown to cause ichthyosis, which affect a variety of different cellular processes, ranging from DNA repair, lipid biosynthesis, cell adhesion, and skin differentiation. Recessive X-linked ichthyosis (RXLI) is the second most common form of inherited ichthyosis. RXLI is caused by mutations in the STS gene on the X chromosome, which encodes microsomal steroid sulfatase. The skin abnormalities of RXLI are caused by the impact of excess cholesterol sulfate, which affects lipid synthesis, organization of the lamellar lipids that provides the skin permeability barrier, corneodesmosome proteolysis, and epidermal differentiation.
As a genetic disorder, RXLI is a life-long condition that can significantly affect domestic life and cause psychological problems for the patients. More effective treatment beyond current symptomatic management is urgently needed. Xiaoyang Wu’s project will explore the possibility that engineered self-amplifying RNA vector can serve as a novel platform for gene therapy of RXLI.
Xiaoyang Wu’s project may serve as proof-of-concept for a novel paradigm for the treatment of patients with genetic skin disorders.
Control of Langerhans cell dynamics and function by the microtubule cytoskeleton
Grantee: Jeffrey Rasmussen, Assistant Professor, University of Washington
Amount: DKK 3,834,520
Grant category: Research Grants in open competition
Year: 2024
Geography: USA
Jeffrey Rasmussen’s project investigates the mechanisms governing Langerhans cells’ immune response in wound healing, particularly the role of the microtubule cytoskeleton.
Skin provides a robust and durable physical barrier essential for regulating hydration and repelling pathogens. Damage to skin must be rapidly resolved to maintain organ homeostasis. Epidermal-resident immune cells known as Langerhans cells use dendritic protrusions to dynamically surveil the skin microenvironment, which contains epithelial keratinocytes and somatosensory peripheral axons.
The mechanisms governing Langerhans cell dendrite dynamics and responses to tissue damage are not well understood. Jeffrey Rasmussen and his lab have developed a tractable system using adult zebrafish to study Langerhans cell dynamics. Initial studies using this system revealed several new discoveries, including: 1) that Langerhans cells are the primary phagocyte for degenerating somatosensory axons; 2) Langerhans cells undergo stereotyped responses to local and tissue-scale keratinocyte wounds; and 3) the actin regulator ROCK regulates key aspects of Langerhans cell wound responses. Despite advances in identifying mechanisms of actin function in Langerhans cells, roles for the microtubule cytoskeleton in Langerhans cell biology remain essentially unknown. In preliminary studies, Jeffrey Rasmussen has developed a novel transgenic reporter for microtubules in Langerhans cells and found that the microtubule cytoskeleton dynamically reorganizes during wound responses. His project aims to determine how the microtubule cytoskeleton contributes to the intracellular trafficking and dynamic wound responses of Langerhans cells.
The results of Jeffrey Rasmussen’s project could lead to new fundamental understandings of Langerhans cell biology and dynamics.
Modulating ECM and Immune Responses by Hybrid mRNA Therapeutics for Fetal-like Scarless Wound Healing
Grantee: Wei Tao, Assistant Professor, Brigham and Women's Hospital
Amount: DKK 3,999,996
Grant category: Research Grants in open competition
Year: 2024
Geography: USA
Wei Tao’s project explores the biological mechanisms to improve wound healing in adults by mimicking the scarless fetal wound healing process. This project aims to engineer a system that replicates the fetal extracellular matrix and immune responses, using mRNA techniques to produce specific proteins and inhibit biological processes leading to scar formation. This system employs lipid nanoparticles for mRNA delivery and hydrogel for controlled release, enabling spatiotemporal control of key components like collagen type III and interleukin-10, thereby reconstituting fetal-like extracellular matrix organization and modulating over-activated immune responses.
The project’s goals include establishing a foundation for future scarless wound healing studies, developing a hybrid mRNA therapeutic platform for skin defects and diseases, and correlating extracellular matrix and immune modulation with subsequent biological processes and outcomes. This research has promising potential for clinical applications in wound care and other dermatological diseases.
The LEO Foundation Award 2024 – Region Americas
Grantee: Shruti Naik, Associate Professor, Icahn School of Medicine, Mount Sinai
Amount: USD 100,000
Grant category: LEO Foundation Awards
Year: 2024
Geography: USA
Dr. Shruti Naik is Associate Professor at the Ronald O Perelman Department of Dermatology, NYU Langone Health, in the US.
She receives the award in recognition of her exceptional scientific achievements, clear long-term career objectives, and innovative vision for skin research – which delves into the complex interactions between immune cells, surrounding skin cells, and skin-dwelling microbes to understand the origins and progression of skin diseases.
SID Future Leaders Retreat
Grantee: Society for Investigative Dermatology
Amount: EUR 25,000
Grant category: Research Networking
Year: 2024
Geography: USA
The Future Leaders Retreat (previously known as Resident and Post Doc Retreat) is a conference hosted by the Society for Investigative Dermatology (SID) each year since 2001. The program format provides a protected space in which residents can interact with senior faculty and established investigators for the purpose of fostering attendee’s interest in academic research careers. The program is a combination of formal lectures and presentation, informal discussions, brainstorming sessions and social activities. The Retreat is held at the time of the SID annual meeting, which allows attendees to establish connections with each other, and to other meeting attendees. These social networks foster collegiality, collaborations, an appreciation for the creative, multidisciplinary nature of science and other productive interactions. Sustained exposure to the entire spectrum of dermatologic research will influence the trainees as they make their career decision, as well as build their enthusiasm for this area of science.
More information: https://www.sidannualmeeting.org/
Epigenetic regulation of sebaceous gland development and homeostasis
Grantee: Brian Capell, Assistant Professor, University of Pennsylvania
Amount: DKK 2,885,457
Grant category: Research Grants in open competition
Year: 2024
Geography: USA
Brian Capell’s project seeks to better understand how epigenetic changes (modifications that do not change the sequence of genomic DNA) regulate the development of sebaceous glands.
Dysfunction of sebaceous glands (SGs) has been linked to a variety of common skin disorders ranging from atopic dermatitis to acne, sebaceous hyperplasia, seborrheic dermatitis and sebaceous tumors.
Brian Capell and his team have recently discovered that through genetic modification of the epigenome, they could promote a dramatic increase in the number and size of SGs (Ko, et al. Developmental Cell. In press. 2024). This surprising result demonstrated the direct role that epigenetics and chromatin organization plays in controlling SG development and abundance. It also suggested that targeting the epigenome might offer new ways to treat disorders characterized by aberrant SG development and activity.
Diseases related to aberrant SG development or activity can have a deleterious effect on both human physical and mental health. Despite this, very little is known of the role of epigenetics in SG development and homeostasis. To address this, Brian Capell’s project aims to test the influence of epigenomic modifiers and modifications upon SG development and disease to further dissect their contribution to the pathogenesis of these very common conditions.
Collectively, this project will address outstanding questions regarding the role of the epigenome in SG development and homeostasis and in common diseases driven by SG dysfunction – diseases that are both understudied and in need of better therapies.