Explore our grantees and awardees

Grant category: Research Networking

Year: 2023

Geography: Denmark

The main purpose of the research stay is to gain hands-on experience on two state-of-the-art technologies, namely spatial transcriptomics, which enables the investigation of gene expression across a tissue and CRISPR technology, which is an advanced method to edit genes within cells to investigate the function of specific genes in health and disease or to modulate cell functionality. These technical skills will be developed as part of two primary research projects to be conducted during the research stay.

Grant category: Education and Awareness Grants

Year: 2023

Geography: Denmark

Re:solve is a not-for-profit global journalistic communication platform managed from Denmark sharing insights and solutions to how we can build more equitable health systems and healthier societies. The purpose of the project granted by Leo Foundation is to create awareness about the burden of skin disease and the burden and complexities of disease stigma through production and publication of two in-depth reports on these topics consisting of a number of articles and other communication pieces. The report on skin disease burden will be supplemented by a high-level roundtable discussion during World Health Assemby 2024, and the disease stigma report by a digital roundtable session and workshop.

Grant category: Education and Awareness Grants

Year: 2023

Geography: Denmark

The project supports the 2023 Biotech Academy Camp which is a week-long science camp for 30 high school students in October. The camp combines theory and lab work, and this year’s program is focused on societal challenges. It is free of charge and also covers participants’ transportation to the camp, has been executed annually since 2008, and is run by master’s and bachelor students from the Technical University of Denmark and the University of Copenhagen.

Grant category: Education and Awareness Grants

Year: 2023

Geography: Denmark

The overall purpose of the pilot project is to increase awareness about atopic dermatitis in children in Greenland and facilitate treatment in remote areas by creating an Eczema School targeting health care staff with no expert knowledge on skin diseases, afflicted children, and their close relatives. There is a high prevalence of atopic dermatitis in Inuit children and the geographical conditions make diagnosis and efficient care difficult. The idea is to establish a school concept in four different areas, which is ready to be implemented, run, and financed locally in the future, in part by the initiative alleviating some of the current strain on the Greenlandic healthcare system.

Grant category: Education and Awareness Grants

Year: 2023

Geography: Denmark

Teach First is a nonprofit recruitment program that enrolls academics in an employment-based training program to become certified schoolteachers, mainly within STEM fields and in schools in socio-economically disadvantaged areas. The purpose of the project is to double the reach of the program by preparing an expansion to western Denmark and to increase the financial sustainability of the program via economy of scale and increase of schools’ share of costs.

Grant category: Research Networking

Year: 2023

Geography: USA

The Barrier Function of Mammalian Skin conference theme is “An Intelligent and Personalized Skin Barrier: Integration and Translation of Cell and Molecular Biology, Bioengineering and Physical Chemistry”. Keynote sessions include presentations on topics such as “Inflammation in Barrier Function and Dysfunction”, “Big Data to Knowledge: Models, Diagnostics and Therapies” and “The “Next Big Question on the Skin Barrier”. 

The Gordon Research Conferences are renowned for their excellent scientific programs and are unique in that each conferee agrees that any information presented at a Gordon Research Conference or Gordon Research Seminar, whether in a formal talk, poster session, or discussion, is a private communication from the individual making the contribution and is presented with the restriction that such information is not for public use. 

Grant category: Research Networking

Year: 2023

Geography: USA

The Montagna Symposia on the Biology of Skin are a very well-established conference, similar to a Gorden Conference, bridging the gap between basic research and dermatology. The meeting brings together scientists and physicians from academics to industry to foster interdisciplinary communication and collaboration in basic, translational and clinical research and practice, facilitating development of new collaborations, research and therapies for cancer, inflammatory diseases and other skin conditions. It provides a venue for the participation of high-profile, established speakers and up-and-coming stars in skin disease research and dermatology practice from around the world. The meeting facilitates the coming together of established researchers and clinicians with residents, fellows, and students; and representatives from government, foundations, and industry in a variety of fields and specialties, fostering the cross-pollination of ideas that is at the heart of breakthroughs in translational dermatology. 

Grant category: Research Grants in open competition

Year: 2023

Geography: Denmark

This project of Ulrich auf dem Keller aims to elucidate the potential role of a set of recently discovered proteins in atopic dermatitis that may contribute to disease development.

Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects people of all ages. It is one of the most common skin diseases, affecting approximately 10-20% of children and 1-3% of adults worldwide. AD can be a frustrating and uncomfortable condition that can significantly impact a person’s quality of life.

Despite extensive research it is not fully clear, if AD is primarily caused by a defect barrier function of the skin, allowing uncontrolled entry of environmental allergens that trigger an immune response, or by immunological disorders that in turn weaken the skin’s protective barrier, exaggerating the disease in a vicious cycle. Most likely, both contribute to predisposition and development of AD, but there are differences between patients which call for customized therapies.

Together with basic skin researchers in Switzerland and dermatologists in Germany, Ulrich auf dem Keller has identified proteins in non-lesional skin of AD patients whose activities might impair skin barrier integrity mostly independent of an immune response. This project will use human skin models and advanced protein analytics to understand if and how they might exert these detrimental activities and thereby contribute to predisposition to AD in affected individuals. Moreover, they will test their findings in samples from AD patients with a long-term aim to contribute to new strategies for development of therapeutics as alternatives to frequently applied emollients in barrier repair therapy.

Grant category: Research Grants in open competition

Year: 2023

Geography: USA

Macrophages, especially anti-inflammatory macrophages, are essential biological players in the process of dermal wound healing. However, maintaining an M2 phenotype within the inflamed wound microenvironment is quite challenging due to secretion of inflammatory cytokines from the wound. To overcome this limitation, Samir Mitragotri and his team have invented polymer micro-disks (“backpacks”) that carry potent anti-inflammatory agents. These “backpacks” are uniquely designed to possess a discoidal shape which keeps them attached to the monocyte/macrophage surface without them being taken up by the cell, and ensures continuous delivery of the anti-inflammatory agents to the cell carrying the backpack without elevating systemic drug concentrations. The project aims to develop a protocol to deliver such “backpack”-laden monocytes only once into the wound, where they can differentiate into macrophages and maintain themselves in the anti-inflammatory phenotype for an adequate time period to induce wound healing. The “backpack” technology has been pioneered by Samir Mitragotri and his lab. This novel strategy appears to have a unique advantage to control macrophage phenotype only for a pre-determined time, thus representing a promising new approach to dermal wound healing treatment.

Grant category: Research Grants in open competition

Year: 2023

Geography: United Kingdom

Dr Peter Arkwright’s project aims to functionally characterize a group of recently discovered anti-inflammatory bacterial substances and investigate their potential therapeutic value in atopic dermatitis.

Staphylococcus aureus is unique in being the only bacterial species that consistently triggers flares in atopic dermatitis (AD). In previous work, also supported by the LEO Foundation, Dr Peter Arkwright, Dr Jo Pennock, and their team at the University of Manchester discovered “Sbi” as the unique factor produced by this bacterium that initiates AD in skin cells. Recently, they have identified factors produced by skin bacteria that completely block Staphylococcus aureus-induced AD, both in the lab and in an eczema mouse model. These factors are small, stable chemicals, made up of both fats and small proteins (lipopeptides).

In a collaboration with Professor Hiroshi Matsuda and Professor Akane Tanaka in Tokyo, Japan, they will apply lipopeptides derived from different bacteria to the skin of mice with AD to determine which are most effective at reducing the clinical dermatitis, itch, and skin damage. They will also explore how these factors work, using cell, protein, and lipid staining techniques. By purifying and characterizing these chemically stable immunosuppressive lipopeptides it is hoped that promising candidates identified here can be taken forward into clinical trials to develop novel therapies for AD.