Explore our grantees and awardees

Grant category: Serendipity Grants

Year: 2025

Geography: United Kingdom

Skin fibrosis is often a sequela of suboptimal wound healing following significant epidermal and/or dermal injury (burns, trauma, major surgeries). Fibrotic material replaces native skin with dense, non-functional connective tissue, ultimately resulting in loss of function and – in the most severe cases – leading to debilitating skin pathologies that limit movement and prevent patient reintegration into society. Ferreira’s lab hosts the only colony of spiny mouse in the UK (Acomys cahirinus). The spiny is, to date, the only mammal capable of completely regenerating skin wounds with minimal scarring following self-amputation. Sofia Ferreira Gonzalez is currently exploring the contribution of different dermal populations to this fibrosis-free wound healing.

Unexpectedly, Sofia Ferreira Gonzalez and colleagues found that spiny dermal fibroblasts have a highly plastic phenotype and are able to convert to many other cell types (neurons, myocytes, chondrocytes). Moreover, they found that spiny fibroblasts secrete factors that enhance migration and proliferation of human dermal fibroblasts and protect them from cellular senescence. Sofia Ferreira Gonzalez aims now to explore these results, defining which mechanisms drive plasticity, migration and proliferation in spiny fibroblasts and adapting them to human fibroblasts. By doing so, Sofia Ferreira Gonzalez aims to establish a radically new approach to skin trauma focused on stimulating tissue regeneration rather than suppressing fibrosis, which has the potential to revolutionize both care and patient outcomes.

Grant category: Serendipity Grants

Year: 2025

Geography: USA

Organisms are continuously bathed in a rich milieu of olfactory compounds. Defined by their ability to elicit the sense of smell, these molecules, and the receptors that sense them, have profound biological importance. Humans have hundreds of olfactory receptors, but paradoxically these are often expressed outside of the nasal cavity and on immune cells. Their function in these contexts is almost entirely unknown. The serendipitous finding illustrates that: a) olfactory receptors are enriched in inflamed skin and on lesion infiltrating lymphocytes; and b) odorants directly modulate lymphocyte function. Understanding the role and molecular mechanisms of these pathways in inflammation may open new avenues for treating skin disease with promise for targeted topical approaches.

To explore this serendipitous finding, the research project will combine in vivo models of skin inflammation with expertise in multiomic analyses of hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) patient tissues. The study will determine if exposure to olfactory molecules modulates skin inflammation in vivo, functionally dissect immune cell intrinsic olfactory signaling, and identify signatures of pathway activity in HS and PG.

This work will provide insight into the fundamental biology of immune-olfactory signaling and determine if there is functional relevance for skin inflammation. The project will also test the implications for HS and PG, where novel therapeutic approaches are urgently needed.

Grant category: Serendipity Grants

Year: 2025

Geography: Denmark

“Stretch-mediated tissue expansion” is used to grow extra skin during breast reconstruction. A mouse model mimicking this clinical process was used to unravel fibroblast-epithelial crosstalk supporting keratinocyte self-renewal. Unexpectedly, the research project found that stretching alters gene expression in Schwann cells, which support nerve function, and reduces touch sensitivity. However, how stretching impacts skin nerves and sensation remains unclear. In light of this serendipitous discovery, the project now plans to investigate how Schwann cells contribute to the regeneration and re-innervation of peripheral sensory neurons in stretched skin.

The new research project – SkinSense – will explore how stretching affects peripheral sensory neurons and Schwann cells, which are key to skin sensation. Single-cell transcriptomics and high-resolution imaging will be used to study how peripheral sensory neurons are affected in terms of structure, function, and repair. Based on these findings, gene therapy approaches using adeno-associated viruses will be tested to restore nerve function and recover skin sensation.

Loss of skin sensitivity after breast reconstruction can greatly affect the quality of life of women. Yet, the reasons behind this sensory loss are not well understood. SkinSense aims to uncover the biological causes of this dysfunction and test ways to restore sensation. This research could lead to new treatments that improve sensory outcomes for patients undergoing reconstructive surgery.

Grant category: Serendipity Grants

Year: 2025

Geography: Canada

Francesca Capon unexpectedly discovered that deleterious TCF3 mutations cause a severe form of atopic dermatitis (AD) associated with inflammatory bowel disease (IBD). By querying large-scale genetic repositories, the project also observed that common TCF3 alleles are associated with susceptibility to AD and IBD in the general population. TCF3 encodes a transcription factor that plays a key role in T cell differentiation. Thus, the project hypothesizes that TCF3 mutations cause abnormal T cell activation, leading to skin and gut inflammation. Given severe AD is a risk factor for IBD, it is further proposed that the study of TCF3 mutations will shed new light on mechanisms that may underpin both conditions.

The aim of the study is to validate the involvement of TCF3 in the pathogenesis of AD and IBD. This will be achieved by identifying the immune pathways that are altered by TCF3 dysfunction in skin and gut. The plan integrates:
i) in-vitro studies to determine the impact of TCF3 mutations on protein function
ii) immune phenotyping of T cells from individuals harbouring TCF3 mutations
iii) in-silico analyses to define transcriptional networks driven by TCF3

The project expects to identify TCF3-dependent pathways contributing to AD and IBD pathogenesis. This will shed new light on shared disease mechanisms with potential to inform targeted treatment of individuals affected by both conditions.

Grant category: Serendipity Grants

Year: 2025

Geography: USA

Hailey-Hailey disease (HHD) is a rare genetic disorder causing recurrent skin blistering and infections. Despite linkage to heterozygous (HET) mutations depleting the SPCA1 Golgi calcium pump 25 years ago, HHD lacks proven therapies. Cory Simpson’s LEO-funded research using in vitro HHD models led to two serendipitous discoveries that fuel this grant: (1) a JNK inhibitor intended as a negative control markedly strengthened adhesion among HET keratinocytes; (2) this led them to re-analyze RNAseq data, which revealed an overlooked aberration that may make HHD patients susceptible to pathogens like herpes simplex virus (HSV). Previously they focused on upregulated pathways amenable to drug inhibition; re-examining downregulated genes in HET cells, they found suppression of type 1 interferon (IFN) signaling. These data support their hypothesis that stress-induced JNK activation upon Golgi protein misfolding in HET keratinocytes weakens cell junctions to cause blistering and dampens IFN responses, facilitating viral infection.

To test these ideas, Cory Simpson required new tools and collaborators in immunology and virology, who provided biosensors to visualize and quantify JNK and type 1 IFN activity along with GFP-tagged HSV to infect the HHD models.

The planned work will test if modulating JNK or type 1 IFN in the HHD model can bolster epidermal integrity and suppress viral infection. Thus, the project has potential to directly impact treatment of patients with this orphan disease.

Grant category: Research Networking

Year: 2025

Geography: Japan

In connection with the 50^th annual meeting of the Japanese Society for Investigative Dermatology (JSID) a symposium, presentations and social gatherings for young scientists are being organized.

Grant category: Education and Awareness Grants

Year: 2025

Geography: Denmark

Biotech Academy Camp is a free, annual event organized by Biotech Academy – a non-profit organization run by ambitious students from Danish universities. This project supports three Biotech Academy Camps for 30 high school students from all over Denmark. The camps combine theory and lab work at Technical University of Denmark and expose students to opportunities within commercial R&D through company visits. They are run by master’s and bachelor students from the Technical University of Denmark and the University of Copenhagen. The topic changes every year, but in 2025 the theme will be genetic modification. The camp will focus on how genetic modification can be used to address societal challenges, develop and improve cell factories in industrial contexts, and open up discussions about research ethics.

Grant category: Education and Awareness Grants

Year: 2025

Geography: Denmark

Matematikcenter offers free math support to children and young people in Denmark through local math cafés, the digital platform Webmatematik.dk, and the online math café Webmatlive.dk.

Through its initiatives, Matematikcenter breaks down barriers in mathematics, strengthens students’ skills, helps them succeed in math, and demonstrates how mathematics is an essential part of both education and the job market.

By engaging volunteer role models, Matematikcenter creates a safe learning environment where students can receive support at their level – regardless of where they are.

Grant category: Education and Awareness Grants

Year: 2025

Geography: Denmark

With the album Mininaut Musik, complex scientific topics are transformed into catchy, educational songs for children aged 3–6.

The album includes 8 original songs on topics such as poop, plastic, skin, and plants, giving children extraordinary knowledge about subjects in their immediate world.

Behind the album is Radionauterne, who for over 8 years have created engaging and innovative science communication for children aged 3–10. The project Mininaut Musik stems from Radionauterne’s popular podcast for 3–6-year-olds, Mininaut. The idea is to link the original songs directly to selected podcast episodes – both existing and future ones – thereby creating an extra dimension to an already successful science communication project.

Grant category: Education and Awareness Grants

Year: 2025

Geography: Denmark

“Denmark in the Future Global AI Society” is an ambitious documentary TV series for DR (Danish Broadcasting Corporation) that, in an entertaining format, aims to engage Danes in a debate about artificial intelligence (AI) and the societal changes that come with it.

Across six episodes, the series will follow a number of leading Danish AI researchers who, in a time of transition, are confronted with ethical, political, and existential questions surrounding the technological shift. In the international race for new AI technologies – led by the USA and China – the researchers are pursuing groundbreaking methods and unique data to develop AI solutions that not only make Denmark competitive but also protect its citizens and democracy.