Defining tissue specific signatures of skin immunity in HIV
Grantee: Elizabeth Phillips, Professor, Vanderbilt University Medical Center, United States
Amount: DKK 2,634,927
Grant category: Research Grants in open competition
Year: 2025
Geography: USA
There are currently almost 40 million people globally living with HIV (PLWH) and they face life-threatening allergic skin reactions to medications up to 100 times more often than the general population, yet these conditions remain poorly understood – especially in those with darker skin. Elizabeth Phillips will use a biorepository with samples from more than 500 cases of severe cutaneous adverse reactions (SCAR) to create a detailed HIV skin immune atlas. Using single-cell sequencing and spatial mapping, Elizabeth Phillips and her team will develop understanding at a single cell level of how HIV alters skin immunity in both healthy and inflamed skin and its role in driving SCAR such as drug reaction with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome and toxic epidermal necrolysis (EN). They will identify new ways to diagnose, treat, or prevent SCAR. The project will improve HIV, allergy, and dermatology care while highlighting Africa’s critical role in global health innovation.
Linking intestinal dysbiosis to scleroderma via the metaorganismal TMA-FMO3-TMAO axis
Grantee: Priyanka Verma, Research Fellow, The Regents of the University of Michigan, United States
Amount: DKK 3,852,212
Grant category: Research Grants in open competition
Year: 2025
Geography: USA
Skin pathology in Scleroderma (SSc) involves activated and senescent myofibroblast accumulation, yet their mechanistic role remains unclear, and effective treatments are lacking. Intestinal microorganisms influence SSc pathogenesis, with altered homeostasis and function in patients. These microorganisms produce the pungent trimethylamine (TMA), which is then converted to trimethylamine N-oxide (TMAO) via an enzymatic reaction catalyzed by hepatic flavin-like monooxygenase (FMO3). Together, these observations implicate FMO3 and the gut-TMA-TMAO axis in both fibrotic and vascular pathology in SSc; however, the pathogenic roles of FMO3 in SSc and its mechanism have never been investigated. Here Priyanka Verma will use human samples, cell cultures and animal models to test the hypothesis that FMO3 is an important player in SSc. Better understanding of the role of FMO3, and its regulation of the gut microbiome-TMAO axis in the pathogenesis of SSc could lead to innovative treatment strategies.
Protein synthesis dependencies governing tissue-resident T cell formation and survival in human skin
Grantee: Christoph Ellebrecht, Assistant Professor, University of Pennsylvania, United States
Amount: DKK 3,999,216
Grant category: Research Grants in open competition
Year: 2025
Geography: USA
Millions of people suffer from chronic skin diseases like psoriasis, vitiligo, and alopecia areata, which follow frustrating cycles of treatment, improvement, and relapse. These relapses occur because certain immune cells, called tissue-resident memory T cells, remain hidden in the skin even after symptoms disappear, ready to trigger inflammation again. Christoph Ellebrecht has discovered that these immune cells depend on highly efficient protein production to survive in the challenging, resource-limited skin environment. Christoph Ellebrecht and his team will investigate when and where this protein production efficiency becomes essential for these cells, how it helps them adapt to the skin, and test whether targeting this process can selectively eliminate these cells while preserving normal immune function outside of the skin. This research could lead to new treatments that provide long-lasting remission for chronic inflammatory skin diseases, significantly improving quality of life for millions of patients worldwide.
Elucidating the complex role of NFκB signaling in skin development and dermatitis
Grantee: Rune Hartmann, Professor, Aarhus University, Denmark
Amount: DKK 3,924,000
Grant category: Research Grants in open competition
Year: 2025
Geography: Denmark
Multiple common skin diseases, like psoriasis, are characterized by excessive inflammation of the affected skin. This causes itching and pain and makes wound healing difficult. Thus, skin inflammation is of general discomfort for the affected patients. Anti-inflammatory drugs, for example inhibitors of the TNF signaling pathway, are highly successful in the clinic for some but not all types of skin inflammation. Rune Hartmann’s project aims at a better understanding of the underlying causes of skin inflammation and how to develop better drugs in the future. Furthermore, Rune Hartmann and his team are investigating how the same signaling pathway can drive skin inflammation and thus cause pathology, while being a critical part of healthy skin development. This is critical to understand how to target future drugs specifically towards the pathological inflammation and avoid unwanted side effects.
Novel role of adipocytes in fibrosis
Grantee: Valerie Horsley, Associate Professor, Yale University, United States
Amount: DKK 2,341,792
Grant category: Research Grants in open competition
Year: 2025
Geography: USA
Valerie Horsley’s project will investigate how lipids and adipocyte-derived molecules suppress fibroblast production of proteins that cause fibrosis. Valerie and her team found that adipocytes release lipids during fibrosis and that this prevents fibrosis development. Their work will identify functional mechanisms that can be targeted for future therapies for skin fibrosis, a debilitating and deadly disorder that lacks any current therapies.
The LEO Foundation Award 2025 – Region Americas
Grantee: Christoph Ellebrecht, Assistant Professor in the Department of Dermatology and the Center for Cellular Immunotherapies, University of Pennsylvania, USA
Amount: USD 100,000
Grant category: LEO Foundation Awards
Year: 2025
Geography: USA
Dr. Christoph Ellebrecht is an Assistant Professor in the Department of Dermatology and the Center for Cellular Immunotherapies at the University of Pennsylvania.
He received the prestigious LEO Foundation Award 2024 in Region Americas during the SID annual meeting in San Diego. The award recognizes Dr. Christoph Ellebrecht for his scientific contributions to our understanding of T cell biology in the skin and its diseases.
The LEO Foundation Award – worth USD 100,000 – recognizes outstanding young researchers and scientists from around the world whose work represents an extraordinary contribution to skin research and has the potential to pave the way for new and improved treatments for skin diseases.
Dermatology Research Across Multiple Disciplines (DREAM)
Grantee: Aarhus University and Aarhus University Hospital
Amount: DKK 11,989,450
Grant category: Standalone grants
Year: 2025
Geography: Denmark
The goal of DREAM (Dermatology Research Across Multiple Disciplines) is to unravel the complex mechanisms linking chronic inflammatory and autoimmune skin diseases to systemic complications. By identifying key factors that predict disease progression and multi-organ involvement, the aim is to enhance our ability to forecast individual disease trajectories.
The overall vision of DREAM is to uncover and solve leading research questions in dermatological and associated diseases using a systems medicine approach.
ESDR Future Leaders Academy 2025
Grantee: Thomas Florestan, European Society for Dermatological Research (ESDR)
Amount: EUR 25,000
Grant category: Research Networking
Year: 2025
Geography: Switzerland
ESDR Future Leaders Academy, a 3-day event from 6.-8. November 2025 held in Nice with the theme ’Excellence in skin science, future is ours’. The goal of this initiative is to foster excellence in academic dermatology and encourage gifted young dermatologists to further pursue their careers through guidance and mentoring. The program is primarily open to European residents currently engaged in skin-related research (MD, PhD, Post-Doc). There will be 25 applicants who will be selected to present their current research, along with 7 mentors who will make a more personal and inspiring presentation. Besides scientific sessions there is a strong emphasis on encouraging young people to network and to exchange ideas during the academy.
SID Resident and Post Doc Retreat
Grantee: Rebecca Minnillo, Society for Investigative Dermatology (SID)
Amount: EUR 25,000
Grant category: Research Networking
Year: 2025
Geography: USA
The Resident and Post Doc Retreat is a conference hosted by the Society for Investigative Dermatology (SID) each year since 2001. The program format provides a protected space in which residents can interact with senior faculty and established investigators for the purpose of fostering attendees’ interest in academic research careers. The program is a combination of formal lectures and presentations, informal discussions, brainstorming sessions and social activities. The retreat is held at the time of the SID annual meeting, which allows attendees to establish connections with each other, and to other meeting attendees. These social networks foster collegiality, collaborations, and appreciation for the creative, multidisciplinary nature of science and other productive interactions.
From Flexibility to Dysfunction: The Impact of Oxidative Stress on the Structural Integrity of Skin Elastin
Grantee: Andrea Heinz, Associate Professor, LEO Foundation Center for Cutaneous Drug Delivery, University of Copenhagen, Denmark
Amount: DKK 3,987,617
Grant category: Research Grants in open competition
Year: 2025
Geography: Denmark
Elastin is a structural protein essential for human life. It provides the elasticity needed for organs like skin, lungs, and blood vessels, allowing your skin to stretch, your lungs to expand for breathing and your blood to flow smoothly. As we age, factors like oxidative stress can make elastin stiffer, reducing the skin’s elasticity and accelerating the aging process. This can lead to skin conditions, such as thickening and furrowing or increased fragility. Andrea Heinz’ project uses advanced analytical techniques to investigate how oxidative damage affect elastin’s structure and stability, starting with its building block, tropoelastin, and extending to skin elastin. The goal is to understand how these alterations contribute to elastic fiber breakdown and tissue dysfunction. Ultimately, this knowledge will help them understand how elastin damage drives disease and tissue degeneration, which could lead to better treatments that protect tissue elasticity and improve overall health.