Implementation of novel 3-bounce 2-pass ATR FTIR spectroscopy into the Skin Testing for Atopic dermatitis (STAR) study
Grantee: Dr Simon G. Danby, Independent Research Fellow, The University of Sheffield Medical School
Amount: DKK 390,506
Grant category: Research Grants in open competition
Geography: United Kingdom
With this grant, the group led by Simon G. Danby seeks a potentially important technological addition to the ongoing A longitudinal investigation of skin barrier development from birth and the validation of early predictors of Atopic dermatitis (AD) risk: the skin testing for atopic dermatitis risk (STAR) trial (see Grants 2017).
This addition may prove valuable to the group’s envisioned paradigm shift – from management of established AD to primary prevention of the condition.
More specifically, the group will include enhanced ATR-FTIR spectroscopy to quantify biomarkers of skin barrier condition and AD severity in newborns. While existing spectroscopy works in adults and children, its sensitivity has been proven unsatisfactory when measuring newborns.
Working with the equipment manufacturer, the group has developed a solution that increases sensitivity 6-fold. This increase can help better prediction of the risk of AD in the newborn and thus enable targeted emollient intervention right from birth – potentially leading to a reduction of the incidence of the condition as increasing evidence suggests that topical emollient therapy can prevent the initial onset of AD by 50%.
AD is a very common chronic inflammatory skin condition affecting around 20% of children worldwide. The disease often heralds development of allergic diseases such as food allergy, asthma, and allergic rhinitis.
Prof. Michael J. Cork and Mr J. Chittock, The University of Sheffield, United Kingdom
Dame Prof. Tina Lavender and Dr Alison Cooke, The University of Manchester, United Kingdom