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Grant category: Education and Awareness Grants

Year: 2019

Geography: Denmark

Science is a powerful tool to understand and change the world for the better. The national Centre for Learning in Science, Technology and Health in Denmark – Astra* – wants to strengthen and develop science learning to train a new generation of young people with strong science competencies. It is important for the future of Denmark and our role in a globalized world.

One of Astra*’s activities is Unge Forskere (Young Scientists) which is Denmark’s largest talent competition for children from Danish elementary schools and high schools within STEM (Science, Technology, Engineering, and Mathematics).

The Unge Forskere-competition contributes to both talent development through participation in the competition, and it strengthens the work with innovation, idea development and the natural science method in daily teaching. It is a program that focuses both on the most talented young people, and generally strengthens the natural science identity and general science education among children and young people in Denmark.

Grant category: Education and Awareness Grants

Year: 2024

Geography: Denmark

The Natural History Museum of Denmark, University of Copenhagen will establish a free online platform for high schools to support the education of ‘data literate’ citizens with hands-on skills in answering interdisciplinary questions through scientific methodology. The platform will provide free access for Danish high schools to data obtained in the Next Generation Lab initiative, an ongoing citizen science initiative in which students analyze archaeological findings at the museum’s lab using scientific methods, thereby generating large amounts of raw research data. The portal will enable students from all over Denmark to work directly with this data, guided by new educational material that supports its relevance within or across topics such as biology, biotechnology, chemistry, history, Danish language and literature, physics, and social studies.

Visit the Natural History Museum of Denmark’s webpage

Grant category: Research Grants in open competition

Year: 2023

Geography: USA

Caroline Le Poole’s project aims to investigate the potential link between the gut microbiome composition and vitiligo development.

The etiology of vitiligo involves a complex hereditary component, as well as environmental factors that precipitate disease. Caroline Le Poole and her team initially asked whether the gut microbiome impacts T cell-mediated autoimmune depigmentation. Manipulating the gut microbiome by oral antibiotics, they demonstrated a significant impact on vitiligo development in an established mouse model of the disease. Specifically, when using ampicillin to favor gut colonization by Pseudomonas species, they observed accelerated vitiligo development. Meanwhile, neomycin treatment was associated with an abundance of Bacteroides species in the gut, while mice in this group did not develop measurable depigmentation. These and other findings suggest that specific microbes can influence vitiligo development.

Here, they will test the hypothesis that the microbiome is a causative pathogenic factor fueling the autoimmune response to melanocytes causing the hallmark progressive depigmentation seen in vitiligo. The team will use mouse and human fecal transplants and manipulate the diet of vitiligo-prone mice. Moreover, individual microbial species will be introduced into germ-free mice before assessing depigmentation kinetics. Ultimately, therapeutic benefit may be derived from promoting the species that support regulatory T cell activity.

Grant category: Education and Awareness Grants

Year: 2018

Geography: USA

The 2019 Gordon Research Conference on Epithelial Differentiation and Keratinization (GRC-EDK) is the premier international meeting in epithelial biology since 1979. It showcases the latest conceptual and technological advances in epithelial biology bridging basic and translational research.

This 2019 meeting entitled “Innovations in basic and translational epithelial biology” aims to bring together preeminent speakers at the forefront of epithelia development, stem cell biology, cell biology, pathology and therapy.

The main objective is to discuss latest developments and generate synergistic approaches towards future discoveries and therapeutic prospects. To ensure this, over 30% of speakers are from outside the immediate field, 50% did not speak in the 2017 meeting, and over 30% will be selected from submitted abstracts. Finally, a power hour will open a debate on ways to recognize and tackle discriminations in science.

Trainee mentorship will be promoted through the 4^th Gordon Research Seminar on Epithelial Differentiation and Keratinization (GRS-EDK), immediately preceding the GRC-EDK. GRS meetings are organized and featured by trainee scientists providing a unique opportunity to discuss their research and develop life-long collaborations.

The GRS-EDK will also feature a career mentoring panel discussion with emphases on transitioning to independence, careers in academia versus industry, and the importance of gender and racial diversity within science. Collectively, this GRC/GRS will move forward cutting-edge research in the area of skin biology, promote translation of key research findings to clinical practice, and further the careers of early stage investigators to maintain the highest level of innovation of this field in the future.