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Grant category: LEO Foundation Visiting Researchers

Year: 2025

Geography: Denmark

Hidradenitis suppurativa (HS) is a painful, long-lasting skin condition that is hard to diagnose and treat. Patients experience a cycle of blocked hair follicles that eventually burst, leading to repeated inflammation and damage. This ongoing injury alters the skin’s structure, creating large permanent scars in intimate areas. Max Sauerland’s research project studies proteins in skin and blood from over 150 HS patients using an innovative biochemical method that extracts data on thousands of proteins from very small samples. By analyzing how these proteins break down, Max and his colleagues aim to find unique markers that help doctors diagnose HS quickly and choose the best treatment. Computer algorithms will sort patients by their protein “fingerprints,” paving the way for personalized care. Ultimately, their work could lead to a fast, simple test not only for HS but also for other similar or rare skin conditions.

The research visit takes place at Universitätsklinikum Freiburg, Germany.

Grant category: Research Grants in open competition

Year: 2012

Geography: Denmark

Psoriasis patients have increased risk of cardiovascular disease (CVD), which still carries high morbidity and mortality in western societies, and is increasing dramatically in the emerging economies.

Consequently, research directed at the interface between psoriasis and CVD, from the level of epidemiological studies to basic experimental research, is of paramount importance in order to improve overall care for psoriasis patients, as well as supporting the need to seek help to receive treatment.

A research project led by Dr Peter Riis Hansen, Gentofte Hospital, Department of Cardiology P, Denmark, will help to:

• Inform and motivate dermatologists to play a pivotal role in screening and helping patients with psoriasis to prevent an increased risk of CVD
• Motivate patients with psoriasis to, firstly, seek treatment and assessment of their CVD risk and, secondly, improve treatment of psoriasis to reduce the overall immune activation
• Establish a murine model of psoriasis and CVD that is suitable for mechanistic studies and preclinical drug evaluation
• Identify new markers of psoriasis and/or CVD activity that may be relevant for clinical use.

Publications:

Khalid U et al. Psoriasis and new-onset diabetes: a Danish nationwide cohort study. Diabetes Care 2013;6:2404-7

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714512/

Khalid U et al. Psoriasis and risk of heart failure: a nation-wide cohort study. Eur J Heart Fail 2014;16:743-8

http://www.ncbi.nlm.nih.gov/pubmed/24903077

Khalid U et al. Sarcoidosis in patients with psoriasis: a population-based cohort study. PLoS ONE 2014;9(10)e109632

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186869

Khalid U et al. Increased risk of aortic valve stenosis in patients with psoriasis: A nation-wide cohort study. Eur Heart J 2015;36:2177-83

http://eurheartj.oxfordjournals.org/content/36/32/2177.long

Khalid U et al. A nationwide study of the risk of abdominal aortic aneurysms in patients with psoriasis

http://atvb.ahajournals.org/content/36/5/1043.long

Madsen M et al. Effects of TPA-induced experimental psoriasis-like skin inflammation in atherosclerosis-prone apoE knock-out mice. BMC Dermatology 2015

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940745