Mechanisms of deconstruction and reconstruction of dermal fat in injury repair
Grantee: Esther Hoste, Assistant Professor, VIB-UGent Center for Inflammation Research
Amount: DKK 3,600,450
Grant category: Serendipity Grants
Year: 2024
Geography: Belgium
Esther Hoste’s project aims to elucidate the role of regulated cell death in adipocytes in relation to injury repair.
In preliminary studies, funded by her LEO Foundation Award in 2022, and investigating keratinocytes in injury repair, Esther Hoste and her team, to their surprise, observed cell death executioner events in adipocytes, implicating lytic and non-lytic adipocyte death in skin wound healing. While adipocyte plasticity is documented as an integral part of skin repair, little is known about the pathways mediating this process. However, rebuilding the adipocyte layer is crucial for restoring skin function after injury.
JSID Young Investigator Event
Grantee: Akimichi Morita, JSID
Amount: EUR 25,000
Grant category: Research Networking
Year: 2024
Geography: Japan
To strengthen the interactions between young scientists a collegiality night and a symposium are arranged in conjunction with the 49th annual meeting of the Japanese Society for Investigative Dermatology (JSID).
The mission of JSID is to advance the position of dermatology in the interdisciplinary world and to enhance the quality of science and research presentations in dermatology for the purposes of maintaining healthy skin and further advancing the treatment of skin diseases.
Hand Eczema in the Fishing Industry in Greenland
Grantee: Kristina Ibler, Bispebjerg Hospital, Dronning Ingrid’s Health Center, the Greenland Fishing Industry, Greenland University, and University of Copenhagen
Amount: DKK 3,437,000
Grant category: Standalone grants
Year: 2024
Geography: Denmark
The overall vision with this research project is to improve skin health and the quality of prevention and treatment of skin diseases in Greenland and the Arctic societies in general. Around 25% of all inquiries to the health care system in Greenland relate to skin diseases. Arctic indigenous peoples have their own genetic variation and have for centuries adapted to their unique geographical environments and culture. Consequently, medical treatment regimens from other countries most often cannot be directly transferred and used in the Greenlandic health care setting. New knowledge, competences and technologies are warranted for utilization across both prevention, translational and clinical research, and practice.
20% of the Greenlandic population is employed in the fishing industry which stands for 90% of Greenland’s export, making it a critical element in a sustainable community. It is expected that around 30-50% of the employees suffer from hand eczema, often with complicating secondary bacterial infection. As such, contact dermatitis has a significant negative impact on both quality of life and productivity in Greenland. The research project aims to provide some of the missing research data on skin diseases in Greenland. It will investigate the prevalence of contact dermatitis, risk factors, biomarkers, and genetic factors associated with contact dermatitis in the seafood-processing fishing industry, as well as explore the presence of bacterial strains and how they relate to dermatitis.
Full of knowledge (Fuld af viden)
Grantee: Anne Engedal, Videnslyd A/S
Amount: DKK 1,500,000
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
Fuld af viden is a continuation of the well-established science podcast series ‘Kraniebrud’ from Videnslyd. The podcast will investigate interesting phenomena and topics from a fact-based perspective through discussions with invited scientists and visits to their labs and studies. The series will be hosted by experienced science journalists, who will present the listeners to all kinds of phenomena from a different unexpected perspective. The weekly episodes will have an increased focus on younger scientists and their research. It’ll optimize the auditory experience and create shorter episodes that are better suited for the podcast format than the original series.
The LEO Foundation 40th Anniversary Prize
Grantee: Gregor Jemec, Professor of Dermatology and Head of Research at Zealand University Hospital
Amount: DKK 5,000,000
Grant category: Standalone grants
Year: 2024
Geography: Denmark
Gregor Jemec is Professor of Dermatology and Head of Research at Zealand University Hospital.
He receives the LEO Foundation 40th Anniversary Prize for his extraordinary contribution to skin research – especially for his pioneering and persistent work with the chronic skin disease hidradenitis suppurativa (HS).
Gregor Jemec has been researching the skin and its diseases for the past 30 years and is one of Denmark’s most cited skin researchers. He is the author of over 800 publications and one of the world’s leading experts on HS, a skin condition that causes painful boils. Research estimates that one to four percent of the world’s population suffers from HS.
The LEO Foundation Award 2024 – Region EMEA
Grantee: Claire Higgins, Reader, Department of Bioengineering, Imperial College London, UK
Amount: USD 100,000
Grant category: LEO Foundation Awards
Year: 2024
Geography: United Kingdom
Dr. Claire Higgins, is a Reader in the Department of Bioengineering at Imperial College London in the UK,
She receives the award in support of her impressive academic achievements and her remarkable leadership within her research group and to future generations of skin scientists. Her research aims to achieve scarless wound healing in human skin by studying the human hair follicle and understanding how it can be used as a model for skin healing.
Center for Pharmaceutical Data Science Education
Grantee: The University of Copenhagen and the University of Southern Denmark
Amount: DKK 30,000,000
Grant category: Standalone grants
Year: 2024
Geography: Denmark
Center for Pharmaceutical Data Science Education is funded by the LEO Foundation, the Novo Nordisk Foundation and the Lundbeck Foundation with a total of DKK 123 million over a six-year period.
The new center merges two fields of study – the pharmaceutical sciences and data science – and will ensure the students’ qualifications in data science by upgrading relevant compulsory bachelor’s and master’s courses. Artificial intelligence, machine learning and the use of big data open a huge area of knowledge, new data sources and methods, which should be integrated in the best possible way in the pharmaceutical sciences education.
4th annual International Conference on the Science of Science and Innovation (ICSSI)
Grantee: Dashun Wang, Professor, Kellogg School of Management, Northwestern University
Amount: DKK 500,000
Grant category: Standalone grants
Year: 2024
Geography: USA
This interdisciplinary event will convene leading experts in the field of science of science and innovation, aiming to provide a multi-channel platform that brings together both producers (scientists from industry and academia) and consumers (policymakers, publishers, funders, administrators, etc.) of the field.
71st Annual Montagna Symposium: Skin of color Dermatology: The Intersection of Science and Society
Grantee: Oregon Health and Science University
Amount: DKK 170,783
Grant category: Research Networking
Year: 2024
Geography: USA
The goal of the 71st Annual Montagna Symposium, Skin of Color Dermatology: The Interaction of Science & Society, is to promote practicing clinicians, residents, trainees, basic and translational researchers who are underrepresented in science and medicine, assembling leading scientists and clinicians engaged in research and treatment of diseases that disproportionately affect skin of color to share knowledge and foster collaborations.
The event will take place on 17-21 October 2024 in Washington, USA and aim to enable interaction between new and established scientists and dermatologists who work collectively to advance the field of skin research. The format will include short talks organized in sessions by topic, with time for questions and discussion. Young investigators get the opportunity to interact with experienced researchers and clinicians in their fields both formally and informally throughout the meeting, and the meeting provides participants with a springboard for new research activities or clinical practices.
Symposium on Epidermal Differentiation Disorders
Grantee: Maastricht University Medical Center+
Amount: DKK 400,000
Grant category: Research Networking
Year: 2024
Geography: Netherlands
The Symposium on Epidermal Differentiation Disorders (EDD) aims to expand the network of experts within EDD by involving and stimulating the future generations of researchers, clinicians, patient organizations, and industry. Organized by leading EDD experts, the event will bring together these stakeholders from diverse backgrounds to brainstorm, promote collaborative research, and design new trials.
EDD are a group of rare hereditary skin conditions characterized by skin thickening, scaling, and redness caused by pathogenic variants in the involved genes. EDD, which include ichthyosis and palmoplantar keratoderma, may affect only skin and related structures (hair, nails) or also other tissues in syndromic subtypes (for example, the brain, heart, hair or eyes). No cure is available, and treatments are limited and not effective enough. Because EDD can severely affect quality of life, the unmet need is high, and an improved understanding of its basis will make it easier to develop treatments that target the causes of disease.
The two-day symposium – currently scheduled for 15-16 September 2025 near Paris, France – will review updates on classification of EDD, clinical and genetic discoveries, novel targeted treatments, patient perspectives, and research. In addition to scientific sessions, the symposium emphasizes collaboration and networking opportunities. Panel discussions and a dedicated session for young researchers will encourage knowledge exchange and exploration of innovative approaches.