Epidemiology and genetics of rosacea and co-morbidities
Grantee: Ole Pedersen, Chief physician , Professor, Zealand University Hospital, Køge
Amount: DKK 2,715,598
Grant category: Research Grants in open competition
Year: 2024
Geography: Denmark
Ole Pedersen’s project aims to determine the genetic basis of rosacea and the causal connection between rosacea and its comorbidities.
Rosacea is a common chronic inflammatory skin disease of the face, which may manifest as a bulbous nose, central erythema, flushing, inflammatory papules/pustules, or broken vessels in addition to diverse eye involvement. Severe rosacea has a large impact on the patients’ quality of life, social and psychological well-being and has been linked to many systemic comorbidities including cardiovascular, psychiatric, neurological, and cancer diseases.
Ole Pedersen’s project aims to identify the genetic pathways of rosacea and determine the causal connection and modifiable risk factors to previously reported systemic comorbidities. He has recently developed a rosacea classification tool and applied it to a deep phenotyped cohort of ~55,000 Danes allowing for detailed analysis of association between rosacea, risk factors and co-morbidities. In addition, Ole Pedersen has facilitated genotyping of 500,000 Danes that can be used for genome wide association study meta-analysis with other genetic cohorts from Iceland, Finland, UK and USA to perform the so far largest genetic study on rosacea. Based on this analysis, his project will determine the genetic correlations and perform Mendelian randomization analysis of the causation between rosacea and comorbidities.
Ole Pedersen’s project may provide new understanding of disease pathogenesis and the link to systemic comorbidities, paving the way for developing new treatments and early targeted interventions.
Children’s books: Max and Meta (Max og Meta)
Grantee: Troels Gollander, Forlaget Meta
Amount: DKK 225,000
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
The ‘Max og Meta’ children’s book series targets 4-12-year-olds with a cartoon-like format presenting stories revolving around natural science phenomena. The series is created by an experienced duo, author Troels Gollander and illustrator Lars-Ole Nejstgaard. The project covers two new books in the series, focused on the sensory system and the body, a website targeting primary schools with free educational material related to the two new books, and a podcast exploring the topics of the book series.
The books aim to stimulate STEM interest in children and pre-teens with an educational format that is both ‘family-friendly’ and relevant for lower secondary school.
Biotech Academy Camp 2024 – Microbiology
Grantee: Victoria Francke, Biotech Academy (DTU Bioengineering)
Amount: DKK 211,260
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
Photo exhibition: My Beautiful Skin (Min smukke hud)
Grantee: Charlotte Näslund Koch, Herlev-Gentofte Hospital
Amount: DKK 210,000
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
Digitalt univers til databearbejdning af citizen science-genererede forskningsdata i gymnasiet
Grantee: Marie Rathcke Lillemark, Statens Naturhistoriske Museum
Amount: DKK 1,811,250
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
The Natural History Museum of Denmark, University of Copenhagen will establish a free online platform for high schools to support the education of ‘data literate’ citizens with hands-on skills in answering interdisciplinary questions through scientific methodology. The platform will provide free access for Danish high schools to data obtained in the Next Generation Lab initiative, an ongoing citizen science initiative in which students analyze archaeological findings at the museum’s lab using scientific methods, thereby generating large amounts of raw research data. The portal will enable students from all over Denmark to work directly with this data, guided by new educational material that supports its relevance within or across topics such as biology, biotechnology, chemistry, history, Danish language and literature, physics, and social studies.
Astronomi og naturvidenskab i børnehøjde
Grantee: Mille Marta Andersen, Go Zebra
Amount: DKK 978,420
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
Go Zebra, a non-profit organization dedicated to stimulating children’s curiosity and bridging it to problem-solving and societal challenges through educational material with a special focus on engineering and innovation, joins forces with astrophysicist and science communicator Tina Ibsen in developing a free educational course on astronomy aimed for 4th-grade teachers and pupils. The developed material will become available for free on MeeBook (the learning platform most widely used by Danish schools), and classes participating in the project will have workshops facilitated by Go Zebra at their schools.
The overall ambition is to instill confidence in children that they can understand the world and have the capabilities to solve problems.
Sustaining the Voice of Science: Increase the Impact of STEM Communication Activities at DTU Skylab
Grantee: Christian Daniel Koldbech, DTU Skylab
Amount: DKK 998,333
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
DTU Skylab will produce two video series, in total ten videos, to promote interest in STEM innovation and entrepreneurship. One of the series will consist of documentaries presenting the most significant innovations that have been realized within the DTU Skylab framework. The other series will consist of interviews with in-house experts and Skylab-based student entrepreneurs sharing their experiences and advice for students.
The videos will provide behind-the-scenes insights into the nature of scientific and technological innovation and entrepreneurship.
Hudlægens bord
Grantee: Vibeke Hjortlund, Videnskab.dk
Amount: DKK 1,262,415
Grant category: Education and Awareness Grants
Year: 2024
Geography: Denmark
Videnskab.dk will produce a podcast series of 12 episodes that disseminate science-based knowledge to the public, about skin health and skin/venereal diseases. The series will be hosted by an MD in dermatology and will address several topics selected by a medical panel to reflect frequently asked questions from patients. Each episode will introduce novel research within the field with potential for enabling new or improved treatment, facilitated by Danish researchers. The podcasts are supplemented with popular science articles and short videos.
Structural dissection and dynamic insights into the molecular switch of mast cells and basophils: a blueprint for novel urticaria therapies
Grantee: Rosaria Gandini, Assistant Professor, Aarhus University
Amount: DKK 3,462,144
Grant category: Research Grants in open competition
Year: 2024
Geography: Denmark
Rosaria Gandini’s project investigates the molecular details of the IgE-FceRI complex and its functioning on mast cells and basophils in order to improve treatment opportunities for urticaria.
Urticaria, a common inflammatory skin disorder characterized by itchy wheals, angioedema, or both, manifests in acute (AU) and chronic (CU) forms. It significantly impairs patients’ quality of life, causing sleep disturbances due to pruritus, fatigue, and anxiety. The symptoms arise from the activation of skin mast cells and basophils, leading to the release of histamine and other inflammatory mediators. This activation is initiated by cross-linking and clustering of the complexes between immunoglobulin E (IgE) and its high-affinity receptor, FceRI, which is expressed on the surface of these cells.
The FceRI-IgE complex hence acts as a powerful molecular switch, which initiates the inflammatory cascade and thus provides an attractive target for drug intervention. The structural basis of this activity, however, remains open.
Rosaria Gandini’s project aims to determine the structure of the FceRI-IgE membrane complex using state of the art Cryo Electron Microscopy (cryo-EM).
Successful elucidation of the molecular details of the entire complex and its conformations will allow identification of specific regions on FceRI for targeted intervention. This knowledge will deepen the understanding of the interaction of antibodies with Fc receptors in general and may pave the way for the development of specific and effective treatment of urticaria and related disorders.
Protein stability and misfolding in keratin disorders
Grantee: Rasmus Hartmann-Petersen, Professor, University of Copenhagen
Amount: DKK 2,600,678
Grant category: Research Grants in open competition
Year: 2024
Geography: Denmark
Rasmus Hartmann-Petersen’s project aims to characterize all possible missense variants (changes in genes which introduce a different amino acid in the resulting protein) in human keratins and investigate the importance of these variants in associated diseases.
Keratins are intermediate filament proteins that form a cytoskeletal network within cells. They are expressed in a tissue-specific fashion and form heterodimers, which then further oligomerize into filaments. Variants in several keratin encoding genes are linked to a range of hereditary disorders, including several epidermal skin diseases. On the molecular level, some pathogenic keratin variants appear to cause aggregation of the keratins.
In Rasmus Hartmann-Petersen’s project it is hypothesized that most keratin-disorders are protein misfolding diseases, i.e. diseases where the underlying genetic variants cause misfolding of the encoding protein. Rasmus and his team aim to explore this hypothesis by using computational tools, including large language models (a specific form of AI). They will test the validity of the computational predictions through focused cellular studies on selected keratins and identify components regulating keratin turnover.
The results will highlight the underlying molecular mechanisms for keratin-linked human disorders and provide predictions on the severity of all possible (both known and yet unobserved) coding variants in human keratin genes. The results could be of diagnostic value, but may also highlight the cellular protein folding and protein quality control machinery as potential therapeutic targets.