SKINTEGRITY 2027: Merging Science, Technology and Medicine for Skin Health

Grantee: Professor Sabine Werner, ETH Zürich, Switzerland, on behalf of SKINTEGRITY.CH

Amount: DKK 446,098

Grant category: Research Networking

Year: 2025

Geography: Switzerland

The SKINTEGRITY 2027 conference will take place from January 28-30, 2027, in Davos, Switzerland, to celebrate the 10-year anniversary of the collaborative research consortium SKINTEGRITY.CH. It brings together basic scientists, clinicians and engineers from academia or industry, whose work helps to understand, diagnose and treat poorly healing wounds, inflammatory skin diseases and skin cancer. It will feature presentations from world leaders in these fields as well as shorter presentations, which will mainly be given by early career researchers. Additional research highlights will be presented in the form of a poster. This international and interdisciplinary conference will promote collaborations across disciplines, educate the next generation of skin researchers and clinical dermatologists, rheumatologists and surgeons, and will help to turn new scientific discoveries into better diagnostic approaches and treatments for patients.

Regulation of Gasdermin proteins in keratinocytes: non-cytolytic functions and post-translational control in inflammatory skin disease

Grantee: Mark Mellett, Group Leader, University of Zurich, Switzerland, Switzerland

Amount: DKK 3,373,693

Grant category: Research Grants

Year: 2025

Geography: Switzerland

Treatments for chronic inflammatory skin diseases rely on immunosuppression, which can increase infection risk and can fail to fully control disease. Keratinocytes of the epidermal barrier also actively drive inflammation. A protein family called the Gasdermins may play a key role in mediating release of inflammatory mediators from cells by forming pores in the cell membrane. At very high activity this kills the cell, but at lower activity these pores may allow controlled release of inflammatory signals, shaping communication between skin cells and immune cells.

This project will investigate:

1. How keratinocytes use Gasdermins for signaling without dying.

2. How chemical modifications fine-tune Gasdermin activity.

3. How these processes are altered in chronic inflammatory diseases, such as psoriasis and atopic dermatitis.

By identifying targets and biomarkers, this research could pave the way for new therapeutic avenues of exploration for inflammatory skin diseases.

Mitochondrial transfer in wound healing

Grantee: Sabine Werner, Professor, ETH Zürich, Switzerland

Amount: DKK 3,560,550

Grant category: Research Grants

Year: 2025

Geography: Switzerland

Chronic wounds or hypertrophic scars affect a large percentage of the population world-wide, but the therapeutic options are still limited. The development of innovative wound therapeutics requires a thorough understanding of the mechanisms underlying normal and impaired healing. This project will study a new regulatory mechanism in wound healing – the transfer of metabolically highly active cell organelles (mitochondria) between different cell types and the functional consequences for wound healing. We will use state-of-the art cell culture and mouse models to determine if mitochondrial transfer has beneficial effects on recipient cells and if this promotes the wound healing process. Through collaboration with clinical partners, we will determine the importance of our findings for normal and impaired healing in humans. The results will pave the way for the development of new wound therapeutics that target mitochondrial transfer or proteins regulated by this process.

Epidermolytic Ichthyosis Global Symposium

Grantee: Helen Lill, CH, Head of Research on behalf of the Symposium

Amount: DKK 158,000

Grant category: Research Networking

Year: 2025

Geography: Switzerland

The EI Cure Project and EI Cure Project Research Alliance will host a 2-day symposium dedicated entirely to rare genetic skin disease Epidermolytic Ichthyosis. The symposium will be held at the Zurich Careum, Switzerland from March 19th to 20th. The full-day presentations, for interested individuals and coming researchers, include the following themes:

  • Patient and Parent Perspectives
  • Clinical Classifications and Current Care
  • Proteomics and Drug-Repurposing
  • Gene-Editing Research Updates

ESDR Future Leaders Academy 2025

Grantee: Thomas Florestan, European Society for Dermatological Research (ESDR)

Amount: EUR 25,000

Grant category: Research Networking

Year: 2025

Geography: Switzerland

ESDR Future Leaders Academy, a 3-day event from 6.-8. November 2025 held in Nice with the theme ’Excellence in skin science, future is ours’. The goal of this initiative is to foster excellence in academic dermatology and encourage gifted young dermatologists to further pursue their careers through guidance and mentoring. The program is primarily open to European residents currently engaged in skin-related research (MD, PhD, Post-Doc). There will be 25 applicants who will be selected to present their current research, along with 7 mentors who will make a more personal and inspiring presentation. Besides scientific sessions there is a strong emphasis on encouraging young people to network and to exchange ideas during the academy.

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Deciphering the coronin 1 pathway for selective inhibition of inflammatory skin diseases

Grantee: Jean Pieters, Principle Investigator, Biozentrum, University of Basel, Switzerland

Amount: DKK 3,989,627

Grant category: Research Grants

Year: 2025

Geography: Switzerland

Inflammatory skin diseases such as atopic dermatitis and psoriasis are debilitating and chronic conditions characterised by the appearance of rashes and scaly plaques. The symptoms are caused by overactivation of the immune system in which T cells play a key role. Current treatments are known to suppress the entire immune system or target pathways required for appropriate immunity and therefore are associated with significant risks for infections and cancer. Jean Pieters and his laboratory has recently defined a pathway that is selectively involved in T cell-mediated inflammatory skin disorders while being dispensable for normal immunity. Within this project Jean Pieters and his team aims to investigate the molecular mechanisms involved, and explore the potential of targeting this pathway as a therapeutic strategy for the suppression of skin inflammation while maintaining overall immunity. The results from this work may allow the delineation of hitherto unexplored and steroid-sparing therapies for inflammatory skin disorders.