Atopic dermatitis in Sub-Saharan Africa: exploring immune phenotypes and mycobiome
Grantee: Marie-Charlotte Brüggen, Assistant Professor, University Hospital Zürich
Amount: DKK 1,886,076
Grant category: Research grants in open competition
The goal of this project is to improve the understanding of atopic dermatitis (AD) in Sub-Saharan Africa by characterizing the immune responses and potential changes in the associated skin and gut mycobiome (the composition of fungi found in a defined area) in AD patients from a dermatological clinic in Moshi, Tanzania. Subsequently, the results will be compared with equivalent data from Central European AD patients to identify similarities and differences.
As previous studies in this area is practically non-existing, this study will be a first step towards understanding the immune phenotype of Sub-Saharan Africa AD and how environmental factors like the fungi of the skin and gut could influence it. This will be important with regard to future treatment options of AD in the region.