Systematic Profiling of Cytokine Responses for Targeted Treatment of Inflammatory Skin Diseases
Grantee: Thierry Nordmann, Dr. med. Dr. phil. nat. (MD/PhD), Max Planck Institute of Biochemistry, Germany
Amount: DKK 3,962,323
Grant category: Research Grants in open competition
Year: 2025
Geography: Germany
Chronic inflammatory skin diseases affect a quarter of the world’s population, but accurately diagnosing and effectively treating these conditions remains a challenge. This is largely because we do not fully understand how skin cells respond at the protein level to the numerous inflammatory signals. In this project, we will create such a molecular dictionary using “omic technologies”, characterizing how skin cells react to a wide range of inflammatory signals (cytokines). Just as a language dictionary allows us to interpret the meaning of words, our molecular dictionary will enable us to understand the complex language of inflammation in diagnostic biopsies of the skin. In combination with artificial intelligence, we will use this dictionary to select the optimal therapy for the individual patient suffering from an inflammatory skin disease. This has the potential to improve patient outcomes while reducing side-effects and costs of ineffective therapies.