Delineate TSLP-driven immune tolerogenic axis in the skin
Grantee: Mei Li, Research Director, Team leader, Institut de Génétique et de Biologie Moléculaire et Cellulaire, France
Amount: DKK 3,994,813
Grant category: Research Grants in open competition
Year: 2025
Geography: France
The skin is the body’s primary barrier against physical insults and microbial pathogens. It also functions as an active immune organ, both in its homeostatic state and during inflammation. Understanding of mechanisms underlying cutaneous immunity and how they contribute to tolerogenic or immunogenic signaling pathways, is crucial to develop therapeutic strategies for different skin diseases. For example, efforts have been made to develop immunotherapy to induce immune tolerance in allergies and autoimmune disorders. Mei Li’s study is based on recent identification of a key regulatory pathway in promoting skin immune tolerance. Mei Li and her team’s objective is to delineate the nature and function of this new regulatory pathway across AD, allergies and vitiligo to develop proof-of-concepts to raise new immunotherapy strategies. The mechanisms and targets discovered in this study may also be applicable to other inflammatory skin diseases.