Adherens Junction Dysfunction in Hidradenitis Suppurativa
Grantee: Amanda Nelson, Assistant Professor, The Pennsylvania State University
Amount: DKK 3,996,947
Grant category: Research Grants in open competition
Year: 2022
Geography: USA
Amanda Nelson’s project investigates the role of two proteins, E-cadherin and p120, in the relatively common inflammatory skin disease Hidradenitis Suppurativa (HS), which is characterized by skin lesions that cause intense pain, odor, drainage and scarring.
The cause of HS remains unclear, and this limits the current treatment options. The current hypothesis is that there is a blockage in the hair follicle unit, which triggers the immune response. Amanda and her team have found that E-cadherin and p120, both important for skin integrity, are lost in HS-affected skin, and their project seeks to understand how this loss may contribute to the hair follicle breakdown and subsequent inflammation. If the link is proven it may provide novel approaches for treatment of HS.
Towards a Cure of Genodermatoses: Intraepidermal Delivery of Gene Editing Tools Leveraging Smart Delivery Systems
Grantee: Sarah Hedtrich, Associate Professor, Charité Hospital Berlin
Amount: DKK 4,183,544
Grant category: Research Grants in open competition
Year: 2022
Geography: Germany
Sarah Hedtrich, who is also Associate Professor at the Faculty of Pharmaceutical Sciences of the University of British Columbia, leads this project focusing on developing novel ways to treat genetic skin diseases through intra-skin delivery methods.
Skin diseases caused by specific genetic defects (genodermatoses) are often rare but can be severe and even life threatening – like epidermolysis bullosa. To cure such diseases, the genetic errors which cause the diseases would need to be corrected. In recent years there have been major advances in targeted gene editing – not least with the CRISPR/Cas system which allows for both tissue- and cell-specific correction.
However, while the skin is readily accessible it has two features which impede such treatment: Firstly, the skin’s barrier function makes efficient delivery difficult, and secondly, as the skin is an epithelium with rapid turnover of the cells, a persistent cure involving gene editing must reach the stem cells which lie at the base of the epidermis, the outer layer of the skin.
Sarah and her team, with expertise in both dermatology, gene editing and topical drug delivery, aim to develop such a delivery system for gene correction treatments using microneedles and nanocapsules, and will investigate its efficiency in both human skin samples and bioengineered skin (disease) models.
Chemical compounds that impede the pathogenic effects of Staphylococcus aureus in atopic dermatitis
Grantee: Tim Tolker-Nielsen, Professor, University of Copenhagen
Amount: DKK 3,236,161
Grant category: Research Grants in open competition
Year: 2022
Geography: Denmark
The project by Tim Tolker-Nielsen aims to identify novel chemical compounds as potential drug leads for treating bacterial involvement in atopic dermatitis. The present project builds on findings from another LEO Foundation grant, which discovered a central factor, Sbi, responsible for the virulence (the ability to cause disease) of the bacteria Staphylococcus aureus in atopic dermatitis flares. As this factor appears to be unique to that bacterium it can be targeted with minimal impact expected on beneficial commensal (i.e. non-pathogenic) bacteria. Tim and his team will utilize existing libraries of chemical compounds to screen for lead candidates that can prevent the production of Sbi and which may be developed into a future treatment for atopic dermatitis flares.
The LEO Foundation Award 2022 – Region Americas
Grantee: Dr. Shadmehr Demehri, Associate Professor, Massachusetts General Hospital
Amount: USD 100,000
Grant category: LEO Foundation Awards
Year: 2022
Geography: USA
Dr. Shawn Demehri is Associate Professor at the Department of Dermatology at Massachusetts General Hospital, USA.
He receives the award for his more than noteworthy contributions to the dermatology field, his truly exciting trajectory within skin research as well as his clinical skills. Dr. Demehri is a brilliant and exceptionally talented physician-scientist who leads a creative and accomplished research team studying the intersection between the immune system and early cancer.
SID Resident and Post Doc Retreat
Grantee: Society for Investigative Dermatology
Amount: EUR 15,000
Grant category: Education and Awareness Grants
Year: 2022
Geography: USA
The SID mission is to advance the sciences relevant to skin disease through education, advocacy and scholarly exchange of scientific information.