Search Results for The Science Olympiads
12th JSID Young Academician-Fostering Seminar (Kisaragi Juku)
Grantee: Japanese Society for Investigative Dermatology
Amount: EUR 15,000
Grant category: Education and Awareness Grants
Year: 2021
Geography: Japan
The mission of the Japanese Society for Investigative Dermatology (JSID) is to advance the position of dermatology in the interdisciplinary world and to enhance the quality of science and research presentations in dermatology for the purposes of maintaining healthy skin and further advancing the treatment of skin diseases.
Education and Awareness Grants (round 2)
Olivier Bohuon steps down from the Board of Directors at LEO Pharma
…Founded in 1908 and owned by the LEO Foundation, LEO Pharma has devoted decades of research and development to advance the science of dermatology, setting new standards of care for…
The LEO Foundation appoints two new members of its Board of Trustees and gets new vice chairman
…Karin Jexner Hamberg, Senior Vice President, Medical & Regulatory Science, H. Lundbeck A / S, Denmark. At the same time, existing board member Eivind Kolding has been appointed new vice…
The LEO Foundation elects new Board members
…medical specialist in biochemistry, internal medicine and medical endocrinology with an extensive career in medical and clinical science. Schwarz sits on various scientific boards and is an experienced reviewer for…
The LEO Foundation Award 2010 – Gold Award
Grantee: Dr. Jacob Pontoppidan Thyssen
Amount: DKK 1,000,000
Grant category: LEO Foundation Awards
Year: 2010
Geography: Denmark
Presented to young Danish dermatology researcher and MD Jacob Pontoppidan Thyssen for his important contributions to the field of skin disease and contact allergy science.
Dr. Thyssen’s research provides conclusive evidence that the Danish initiative to regulate nickel exposure, started in 1990, has succeeded in decreasing the prevalence of nickel allergy in Danish women. His findings, published in The New England Journal of Medicine last year, hold global relevance and may contribute to interventions in other nations, including the US.
Bloom Festival 2020-2021
Grantee: Svante Lindeburg, Golden Days
Amount: DKK 1,000,000
Grant category: Education and Awareness Grants
Year: 2019
Geography: Denmark
Bloom – at the core:
Bloom is an innovative festival about science and nature, which enlighten us on the Universe, the World and Ourselves. Framed in the lush Søndermarken at Frederiksberg in the heart of the capital city of Denmark, where some of the World’s greatest scientists, poets and philosophers have found inspiration through history, Bloom emerges each Spring as a sensual, experimental and thought-provoking festival version of natural sciences.
By uniting the best from the world of festivals with the best from the scientific world, Bloom arm wrestles with Life’s greatest questions and over two days invite the audience to debates, talks, laboratories, conversations and nature walks under open skies.
Bloom Festival 2019
Grantee: Svante Lindeburg, Golden Days
Amount: DKK 500,000
Grant category: Education and Awareness Grants
Year: 2018
Geography: Denmark
Bloom – at the core:
Bloom is an innovative festival about science and nature, which enlighten us on the Universe, the World and Ourselves. Framed in the lush Søndermarken at Frederiksberg in the heart of the capital city of Denmark, where some of the World’s greatest scientists, poets and philosophers have found inspiration through history, Bloom emerges each Spring as a sensual, experimental and thought-provoking festival version of natural sciences.
Prepared and communicated by some of the brightest scientists, thinkers, and artists of our time from here and abroad. By uniting the best from the world of festivals with the best from the scientific world, Bloom arm wrestles with Life’s greatest questions and over two days invite the audience to debates, talks, laboratories, conversations and nature walks under open skies.
Replicating peeling skin diseases in a living skin model
Grantee: Professor Peter R Hull, PhD (Med) FRCPC. Head, Division of Clinical Dermatology and Cutaneous Science, Dalhousie University, Halifax, Nova Scotia
Amount: DKK 2,180,881
Grant category: Research Grants in open competition
Year: 2017
Geography: Canada
A number of chronic skin conditions have peeling of the skin as the dominant expression; akin to skin peeling following severe sunburns. In the chronic conditions, peeling is cyclical or continuous, often affecting hands, feet, or the body. Today, there is no effective treatment for these conditions, leaving patients subjected to trial and error with a variety of non-effective and often also expensive therapies.
A number of abnormal gene variants have been found to disrupt the normal maturation of the skin. Using a gene manipulation tool known as CRISPR, the team led by Dr Hull will build understanding of the role of four known genes causing skin peeling syndromes. This will be done by replicating the diseases in cell cultures grown into full thickness skin and studying the cellular and biochemical changes caused by the induced gene modifications.
Of particular interest is cathepsin B, an enzyme that has been found to play an important role in peeling associated with the skin disorder, keratolytic winter erythema.
The team’s hypothesis is that there is an important and dynamic interplay and balance between a number of enzymes in the outer layers of the skin and that if this balance favours the activity of cathepsin B, peeling results.
If this is shown, it may be clinically very relevant as there are a number of known compounds that inhibits cathepsin B and which then could be used to treat patients with chronic peeling as a consequence of their skin disorder.
Cytosolic genome DNA fragments as a trigger of keratinocyte proliferation in psoriasis
Grantee: Dr Koichi Suzuki, PhD, Professor, Department of Clinical Laboratory Science, Faculty of Medical Technology, Teikyo University
Amount: DKK 460,000
Grant category: Research Grants in open competition
Year: 2016
Geography: Japan
Release of double-stranded (ds)DNA from keratinocytes has been linked to the initiation of psoriasis via induction of an immune response. Furthermore, vitamin D has been reported to interfere with this mechanism. Vitamin D analogues are widely used for treatment of psoriasis and have a well-known effect on keratinocyte proliferation and differentiation.
Dr Koichi Suzuki and his Japanese-Chinese team hypothesise that the release of dsDNA may more directly induce the characteristic hyper-proliferation and abnormal differentiation of keratinocytes seen in psoriasis by a TNFα-mediated inflammatory process in keratinocytes.
The team will investigate this hypothesis and the impact of vitamin D by the use of keratinocyte cultures and psoriasis skin samples from patients treated with a vitamin D analogue.
The project may further enhance our understanding of the complex molecular events underlying psoriasis and how vitamin D treatment may intervene in the pathogenic process, potentially revealing new aspects of the mode of action of vitamin D.