Search Results for The Science Olympiads
The LEO Foundation awards DKK 14 million to five new skin research projects
…a special regenerative salamander (axolotl) are used as models. Peter Reddien’s research project is a basic skin science project with a novel approach to understanding the skin’s potential for regeneration….
What if our immune system holds the secret to preventing skin cancer?
…his continuous work and close dialogue with patients. And when asked what has shaped and inspired his career in science so far, Dr. Demehri highlights his dedication and passion for…
Full thickness skin models from human pluripotent stem cells for identification and testing effectiveness of personalised therapies in atopic dermatitis
Grantee: Dr Dusko Ilic, MD, PhD, Reader in Stem Cell Sciences, Kings College London, Dr Reiko Tanaka, Lecturer, Department of Bioengineering, Imperial College, London, Dr Patrick Harrison, Senior Lecturer, Department of Physiology, University College Cork, Ireland, and Professor Theodora Mauro, MD, Professor of Dermatology, San Francisco Veterans Affairs Medical Center, USA
Amount: DKK 9,980,000
Grant category: Research Grants in open competition
Year: 2016
Geography: Ireland, United Kingdom, USA
This is an exciting project that, with the international group’s extensive research and know-how in mind, has the potential to create an intriguing base for novel personalised treatments for atopic dermatitis (AD). The project moreover holds an innovation potential that may make it stand out in the emerging global bio-economy.
The prevalence of AD, an inflammatory skin disease resulting in itchy, red, swollen and cracked skin, is constantly increasing. Today, it affects 15-30 percent children and 2-10 percent adults worldwide, presenting a significant economic burden to healthcare systems.
There is no cure for AD, only soothing of the symptoms. In the majority of AD patients, the disease is a consequence of a blend of genetic defects of the skin barrier defects and abnormal immune responses influenced by environmental factors.
Until now, the models used to assess the interplay are not particularly predictive. The group behind this project aims to change this by using the latest advances in stem cell science, gene editing and tissue engineering to develop and validate innovative 3D in vitro models of skin – making the models similar to skin in AD patients by emulating full thickness skin of varying barrier integrity; faulty, partially repaired or intact, and immune response composition.
As part of the project, the group will also develop mathematical computer models to accurately address the predictive, prognostic and therapeutic outcome of personalised AD therapy – in order to address co-dependence of the quantitative and qualitative changes in skin barrier and activation of immune cells.
The 3D models will also be made available to test various novel therapeutic approaches for AD treatment in a patient specific manner.
The LEO Foundation appoints two new members of its Board of Trustees and gets new vice chairman
…Karin Jexner Hamberg, Senior Vice President, Medical & Regulatory Science, H. Lundbeck A / S, Denmark. At the same time, existing board member Eivind Kolding has been appointed new vice…
The LEO Foundation elects new Board members
…medical specialist in biochemistry, internal medicine and medical endocrinology with an extensive career in medical and clinical science. Schwarz sits on various scientific boards and is an experienced reviewer for…
The LEO Foundation Award 2010 – Gold Award
Grantee: Dr. Jacob Pontoppidan Thyssen
Amount: DKK 1,000,000
Grant category: LEO Foundation Awards
Year: 2010
Geography: Denmark
Presented to young Danish dermatology researcher and MD Jacob Pontoppidan Thyssen for his important contributions to the field of skin disease and contact allergy science.
Dr. Thyssen’s research provides conclusive evidence that the Danish initiative to regulate nickel exposure, started in 1990, has succeeded in decreasing the prevalence of nickel allergy in Danish women. His findings, published in The New England Journal of Medicine last year, hold global relevance and may contribute to interventions in other nations, including the US.
Bloom Festival 2020-2021
Grantee: Svante Lindeburg, Golden Days
Amount: DKK 1,000,000
Grant category: Education and Awareness Grants
Year: 2019
Geography: Denmark
Bloom – at the core:
Bloom is an innovative festival about science and nature, which enlighten us on the Universe, the World and Ourselves. Framed in the lush Søndermarken at Frederiksberg in the heart of the capital city of Denmark, where some of the World’s greatest scientists, poets and philosophers have found inspiration through history, Bloom emerges each Spring as a sensual, experimental and thought-provoking festival version of natural sciences.
By uniting the best from the world of festivals with the best from the scientific world, Bloom arm wrestles with Life’s greatest questions and over two days invite the audience to debates, talks, laboratories, conversations and nature walks under open skies.
Bloom Festival 2019
Grantee: Svante Lindeburg, Golden Days
Amount: DKK 500,000
Grant category: Education and Awareness Grants
Year: 2018
Geography: Denmark
Bloom – at the core:
Bloom is an innovative festival about science and nature, which enlighten us on the Universe, the World and Ourselves. Framed in the lush Søndermarken at Frederiksberg in the heart of the capital city of Denmark, where some of the World’s greatest scientists, poets and philosophers have found inspiration through history, Bloom emerges each Spring as a sensual, experimental and thought-provoking festival version of natural sciences.
Prepared and communicated by some of the brightest scientists, thinkers, and artists of our time from here and abroad. By uniting the best from the world of festivals with the best from the scientific world, Bloom arm wrestles with Life’s greatest questions and over two days invite the audience to debates, talks, laboratories, conversations and nature walks under open skies.
Museum assistant – LEO Historical Archives and Museum
…Retrieving and moving artefacts and material in the physical archives. Drafting stories and blog posts for our internal communications channels. About you A Master’s degree in Museology, History, Informational Science,…
Replicating peeling skin diseases in a living skin model
Grantee: Professor Peter R Hull, PhD (Med) FRCPC. Head, Division of Clinical Dermatology and Cutaneous Science, Dalhousie University, Halifax, Nova Scotia
Amount: DKK 2,180,881
Grant category: Research Grants in open competition
Year: 2017
Geography: Canada
A number of chronic skin conditions have peeling of the skin as the dominant expression; akin to skin peeling following severe sunburns. In the chronic conditions, peeling is cyclical or continuous, often affecting hands, feet, or the body. Today, there is no effective treatment for these conditions, leaving patients subjected to trial and error with a variety of non-effective and often also expensive therapies.
A number of abnormal gene variants have been found to disrupt the normal maturation of the skin. Using a gene manipulation tool known as CRISPR, the team led by Dr Hull will build understanding of the role of four known genes causing skin peeling syndromes. This will be done by replicating the diseases in cell cultures grown into full thickness skin and studying the cellular and biochemical changes caused by the induced gene modifications.
Of particular interest is cathepsin B, an enzyme that has been found to play an important role in peeling associated with the skin disorder, keratolytic winter erythema.
The team’s hypothesis is that there is an important and dynamic interplay and balance between a number of enzymes in the outer layers of the skin and that if this balance favours the activity of cathepsin B, peeling results.
If this is shown, it may be clinically very relevant as there are a number of known compounds that inhibits cathepsin B and which then could be used to treat patients with chronic peeling as a consequence of their skin disorder.