From Flexibility to Dysfunction: The Impact of Oxidative Stress on the Structural Integrity of Skin Elastin
Grantee: Andrea Heinz, Associate Professor, LEO Foundation Center for Cutaneous Drug Delivery, University of Copenhagen, Denmark
Amount: DKK 3,987,617
Grant category: Research Grants in open competition
Year: 2025
Geography: Denmark
Elastin is a structural protein essential for human life. It provides the elasticity needed for organs like skin, lungs, and blood vessels, allowing your skin to stretch, your lungs to expand for breathing and your blood to flow smoothly. As we age, factors like oxidative stress can make elastin stiffer, reducing the skin’s elasticity and accelerating the aging process. This can lead to skin conditions, such as thickening and furrowing or increased fragility. This project uses advanced analytical techniques to investigate how oxidative damage affect elastin’s structure and stability, starting with its building block, tropoelastin, and extending to skin elastin. Our goal is to understand how these alterations contribute to elastic fiber breakdown and tissue dysfunction. Ultimately, this knowledge will help us understand how elastin damage drives disease and tissue degeneration, which could lead to better treatments that protect tissue elasticity and improve overall health.
SERS-Enabled Wound-Sampling Patches for Rapid Infection Monitoring
Grantee: Gohar Soufi, Postdoc, Technical University of Denmark, Denmark
Amount: DKK 3,999,657
Grant category: Research Grants in open competition
Year: 2025
Geography: Denmark
Millions of people suffer from infected wounds each year, which can lead to serious complications or even death if untreated. Current methods for diagnosing wound infections are slow and require specialized laboratories. Our project aims to create a simple, portable device that uses advanced materials to detect infections quickly and accurately right at the patient’s bedside. This technology could revolutionize how infections are diagnosed, helping doctors start treatments sooner and improving patient outcomes.
50 NEW Wild Scientific Experiments (50 NYE vilde videnskabelige forsøg)
Grantee: Kristoffer Frøkjær, Science Media Company
Amount: DKK 127,000
Grant category: Education and Awareness Grants
Year: 2025
Geography: Denmark
The children’s book ’50 NYE vilde videnskabelige forsøg’ (Eng.: 50 NEW Wild Scientific Experiments) is a follow-up to the book ‘Manden der fik skåret sin hjerne i skiver og 49 andre vilde videnskabelige forsøg’. This publication will present exciting scientific discoveries and experiments, aiming to increase curiosity about science among the target group of 9-14-years-olds. The book will be published by Gads Forlag and will be accompanied by a related podcast series featuring some of the stories and content from its pages.
Scientific Studies – Didactic, Student Motivation and Everyday Realism (Naturvidenskabelige undersøgelser – didaktik, elevmotivation og hverdagsrealisme)
Grantee: Kristoffer Brink Ladefoged, Danmarks Naturfagslærerforening
Amount: DKK 900,000
Grant category: Education and Awareness Grants
Year: 2025
Geography: Denmark
Danmarks Naturfagslærerforening (Eng.: The Danish Association of Science Teachers) is publishing an anthology on didactic models and methods facilitating an experimental and investigative approach to natural science teaching in Danish schools – with a main focus on motivating students and offering solutions suited for direct implementation in the everyday teaching effort. The book called ‘Naturvidenskabelige undersøgelser – didaktik, elevmotivation og hverdagsrealisme’ (Eng.: Scientific Studies – Didactic, Student Motivation and Everyday Realism) will be distributed by the teachers’ association to its members and will be available for ordering or downloading for others, for free.
Novel methods and technologies: Spatial transcriptomics, wildlings and 3D skin models
Grantee: University of Copenhagen
Amount: DKK 18,908,400
Grant category: Standalone grants
Year: 2025
Geography: Denmark
Through this grant the LEO Foundation Skin Immunology Research Center is expanding its scientific and technological capabilities by incorporating three new areas of expertise:
- Spatial transcriptomics (in collaboration with the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR))
- Establishment of an animal facility for “wildlings” – a special type of laboratory mice that contain a – controlled – level of microorganisms which make them more akin to real-world animals and provides a more natural model, in particular for interactions with and responses from the immune system.
- Establishment of advanced 3D skin models for experiments building on genetic manipulation of specific cell types from the skin.
Each area is carefully selected to strengthen the center’s focus on performing frontier research within barrier immunology.