{"id":12833,"date":"2024-12-16T10:10:11","date_gmt":"2024-12-16T09:10:11","guid":{"rendered":"https:\/\/leo-foundation.org\/en\/?p=12833"},"modified":"2024-12-16T10:26:45","modified_gmt":"2024-12-16T09:26:45","slug":"15-pioneering-skin-research-projects-receive-leo-foundation-grants","status":"publish","type":"post","link":"https:\/\/leo-foundation.org\/en\/2024\/12\/16\/15-pioneering-skin-research-projects-receive-leo-foundation-grants\/","title":{"rendered":"15 pioneering skin research projects receive LEO Foundation grants"},"content":{"rendered":"\n<div class=\"wp-block-group alignwide\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"has-text-align-right has-small-font-size\"><em>15  talented skin researchers have been awarded a LEO Foundation Research Grant in Open Competition.<\/em><\/p>\n\n\n\n<div style=\"height:36px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><em>16 December 2024<\/em><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">The LEO Foundation awards DKK 56 million to 15 research projects that will improve our understanding of the underlying mechanisms of skin diseases and their symptoms. This latest round of Research Grants in Open Competition saw the highest number of applications in the Foundation\u2019s history.<\/h3>\n\n\n\n<p>In the third and final round of 2024, the LEO Foundation awards 15 international scientists with a research grant. The funding \u2013 totaling just over DKK 56 million (EUR 7.5 million)\u2013 supports cutting-edge research in the field of skin research.<\/p>\n\n\n\n<p>The grantees, representing a diverse geographic spread, hail from institutions such as University College London, the Broad Institute of MIT and Harvard, Albert Einstein College of Medicine, Oslo University Hospital, the Technical University of Denmark and Kyoto University Graduate School of Medicine.<\/p>\n\n\n\n<p>\u201cThe LEO Foundation is proud to support the best skin research projects worldwide that further our knowledge of the skin and its diseases. We aim to improve the lives of millions of people living with skin diseases \u2013 and we believe that scientific findings from these cutting-edge projects will pave the way to do exactly that,\u201d says Anne-Marie Engel, Chief Scientific Officer at the LEO Foundation.<\/p>\n\n\n\n<p>This record-setting round attracted 112 applications, reviewed by the <a href=\"https:\/\/leo-foundation.org\/en\/grants-and-awards\/research-grants\/#sec\">Scientific Evaluation Committee<\/a> (SEC), an international panel of independent experts, who evaluate applications submitted for Research Grants in Open Competition.<\/p>\n\n\n\n<p><strong>Exploring skin from multiple research perspectives<\/strong><\/p>\n\n\n\n<p>The awarded research projects span a broad array of focuses and approaches, from investigating the skin\u2019s sensory nerves to exploring atopic dermatitis and the complex interactions of live bacteria within the skin\u2019s microbiome.<\/p>\n\n\n\n<p>One of the funded research projects focuses on establishing a global research collaboration, the Skin Genetic Consortium (SGC), to study the genetics of skin diseases. Led by Associate Professor Lavinia Paternoster at the University of Bristol in the UK, this initiative will use large-scale genetic data from populations around the world to better understand the genetic causes of skin diseases, identify new drug targets, and improve diagnostics. By developing a platform for harmonized data, streamlined genetic analysis and open result distribution, the project aims to provide scientists globally with an unprecedented and unique resource of high-quality, standardized genetic data on skin diseases.<\/p>\n\n\n\n<p><strong>Focus on early biomarkers in childhood atopic dermatitis<\/strong><\/p>\n\n\n\n<p>Another funded research project focuses on exploring early biomarkers in childhood atopic dermatitis &#8211; a skin condition affecting about 1 in 5 children. The project, led by Ann-Marie Schoos, Clinical Research Associate Professor at Herlev and Gentofte Hospitals in Denmark, seeks to address the reasons why some children outgrow atopic dermatitis while others experience persistent symptoms. The research investigates protein biomarkers \u2014 molecules in the blood that can act as indicators of disease processes \u2014 to better understand atopic dermatitis and improve prediction, prevention, and treatment. While similar studies have been done in adults, research on children, especially in the early stages of atopic dermatitis, is still limited. The goal for Schoos\u2019 team is to develop a simple blood test to identify which children are at risk for severe or long-lasting atopic dermatitis, paving the way for personalized treatment and better outcomes.<\/p>\n\n\n\n<p><strong>Advancing innovative therapies for vitiligo and other autoimmune skin diseases<\/strong><\/p>\n\n\n\n<p>A third project, led by Juli\u00e1n Valero, Assistant Professor at Aarhus University in Denmark, focuses on developing innovative treatments for vitiligo, an autoimmune skin disease in which the immune system destroys pigment-producing cells, leading to loss of skin color. Valero\u2019s team is using RNA aptamers \u2014 tiny RNA molecules that can bind precisely to specific targets \u2014 to deliver treatments directly to affected skin cells. By focusing on the so-called Langerhans cells and associated immune interactions, the research aims to reduce inflammation and reprogram immune cells to stop attacking the skin. Langerhans cells act as the outermost guard of the skin\u2019s immune system. Approaches include delivering anti-inflammatory drugs, reprogramming immune cells, and using aptamers to block harmful immune signals. This approach holds promises for reducing side effects and improving beneficial immune responses and may open the door more broadly to new skin therapies and vaccines.<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-primary-coal-color has-primary-peach-background-color has-text-color has-background has-link-color wp-element-button\" href=\"https:\/\/leo-foundation.org\/en\/grant-category\/research-grants-in-open-competition\/?post_type=grantee&amp;grant-geography&amp;rest=false\">Read more about all 15 grantees and their projects here<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>Next application round in 2025<\/strong><\/p>\n\n\n\n<p>The LEO Foundation calls for applications for research projects focusing on the skin and its diseases on an ongoing basis. The next call is open,&nbsp;with an application deadline of <strong>8 January 2025<\/strong>.<\/p>\n\n\n\n<p>The competition is open to talented skin researchers at PhD level or above from any country. The typical grant amount applied for is DKK 2\u20134 million for a period of 1\u20133 years. Researchers who would like to apply for a LEO Foundation research grant will be able to apply&nbsp;<a href=\"https:\/\/leo-foundation.org\/en\/grants-and-awards\/research-grants\/\"><strong>here<\/strong><\/a>.<\/p>\n\n\n\n<p>Get an overview of current funding opportunities from the LEO Foundation&nbsp;<a href=\"https:\/\/leo-foundation.org\/en\/grants-and-awards\/\"><strong>here<\/strong><\/a>.<\/p>\n\n\n\n<div style=\"height:51px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The LEO Foundation awards DKK 56 million to 15 research projects that will improve our understanding of the underlying mechanisms of skin diseases and their symptoms.<\/p>\n","protected":false},"author":8,"featured_media":12853,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-12833","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>15 pioneering skin research projects receive LEO Foundation grants<\/title>\n<meta name=\"description\" content=\"The LEO Foundation awards DKK 56 million to 15 research projects that will improve our understanding of the underlying mechanisms of skin diseases and their symptoms.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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