Granzyme B: A novel therapeutic target in cutaneous leishmaniasis

Grantee: David Granville, Professor, University of British Columbia, Canada

Amount: DKK 2,023,506

Cutaneous leishmaniasis (CL) is a designated ‘WHO top-neglected tropical disease’, with up to 1 million new cases worldwide annually. CL is an inflammatory skin disease caused by infection with Leishmania parasites that leads to tissue damage, ulcers, and severe scarring, despite current treatment options.

The goal of this project is to provide a key rationale for pursuing Granzyme B (GzmB) as a novel therapeutic target for the treatment of cutaneous leishmaniasis. 

GzmB is a protein that is aberrantly elevated in CL lesions and other inflammatory skin conditions. GzmB activity has been demonstrated to cleave important proteins in the skin, thereby worsening tissue damage, delaying wound healing, and causing scarring in inflammatory patient skin specimens and in experimental models. Importantly, inhibition of GzmB has shown efficacy in delaying these disease phenotypes.  

Using lesional specimens from CL patients, a well-established experimental model, and a GzmB inhibitor, the contributions of GzmB to inflammation, impaired wound healing, and scarring in CL will be delineated in this study. 

Investigation of genetic variation and development of genetically defined cell models for Acne vulgaris therapeutic and cosmetic products evaluation

Grantee: George Church, Professor at Harvard Medical School, Harvard University and MIT, Cambridge, MA, USA

Amount: DKK 3,926,475

Summary available soon.

Deciphering the functional role of circular RNAs in psoriasis

Grantee: Lasse Sommer Kristensen, Associate Professor, Department of Biomedicine, Aarhus University, Denmark

Amount: DKK 2,467,477

Summary available soon.

Atopic dermatitis in Sub-Saharan Africa: exploring immune phenotypes and mycobiome

Grantee: Marie-Charlotte Brüggen, Assistant Professor, University Hospital Zürich, Switzerland

Amount: DKK 1,886,076

Summary available soon.

Molecular investigation of CCL5-hi chronic adult rashes (CCARs)

Grantee: Raymond Cho, Associate Professor, Dermatology, School of Medicine, University of California San Francisco, CA, USA

Amount: DKK 3,330,056

Summary available soon.

Protein aggregation in host defense and skin inflammation

Grantee: Artur Schmidtchen, Professor, Dermatology and Venereology, Department of Clinical Sciences, Lund University, Sweden

Amount: DKK 2,100,000

Summary available soon.

In vivo gene editing for genodermatoses

Grantee: Thomas Kocher, Postdoc, EB House Austria, Salzburg, Austria

Amount: DKK 1,389,845

Summary available soon.

Identification and biological basis of immunomodulation of skin inflammation by S. epidermidis

Grantee: Peter Arkwright, Senior Lecturer, The University of Manchester, United Kingdom

Amount: DKK 4,369,423

Summary available soon.

Deciphering the Role of Non-Coding RNAs in Epidermal Carcinogenesis

Grantee: Andor Pivarcsi, Senior lecturer/Associate Professor, Uppsala Universitet, Uppsala, Sweden

Amount: DKK 4,164,300

Summary available soon.

Rapid Clinical Assessment of Skin Barrier Function by Corneocytes Nanotexture

Grantee: Edwin En-Te Hwu, Associate Professor, Technical University of Denmark, Kgs. Lyngby, Denmark

Amount: DKK 2,824,593

Summary available soon.