Dissecting the Role of Immunometabolism in CD4+ T Cell Skin Residency
Grantee: Tiffany Scharschmidt, Professor and Vice Chair of Research, The Regents of The University of California San Francisco, United States
Amount: DKK 3,416,251
Grant category: Research Grants in open competition
Year: 2025
Geography: USA
Tiffany Scharschmidts seek to understand how CD4+ T cells adapt to and survive in the skin. These cells are crucial for maintaining skin health but also drive diseases like atopic dermatitis and psoriasis. Despite this, we have much still to learn about the biology of CD4+ T cells residing in skin. To fill this gap, Tiffany and her team will use advanced single-cell techniques to study the metabolism of CD4+ T cells in both mouse and human skin. Preliminary data suggest these cells rely on glycolysis, and they aim to explore this further and identify other important metabolic pathways. In the first part of the study, they will use innovative mouse models and CRISPR-Cas9 technology to pinpoint key metabolic needs and regulators. In the second part, they will extend their findings to human skin, examining CD4+ T cells in both healthy and diseased states. The goal is to uncover how metabolism influences skin immune function, which could lead to new treatments for chronic inflammatory skin diseases.
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