Nucleic Acid Ionic Liquids (NAILs) for Topical Skin Applications

Beneficiary: Samir Mitragotri, Harvard John A. Paulson School of Engineering and Applied Sciences

Grant: 2.000.043 DKK

We will develop a novel ionic-liquid formulation for topical delivery of nucleic acids into the skin.

Our ionic liquid enhances lipophilicity of nucleic acids by ~100,000,000 fold and enhances their penetration into the skin. We will demonstrate the feasibility of the platform through delivery and efficacy of two siRNAs. The resulting platform is expected to have broad applications to other nucleic acid drugs including mRNA for the treatment of a wide range of dermatological conditions.

Our ionic liquid platform will open new opportunities for the treatment of dermatological conditions.